Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effect of Cuscutae Semen Extract on Blood Pressure, Regional Cerebral Blood Flow and Pial Arterial Diameter in Rats

토사자가 혈압(血壓), 국소뇌혈류량(局所腦血流量) 및 뇌연막동맥(腦軟膜動脈)에 미치는 영향(影響)

  • Kang Sung-Yong (Department of Herbology, College of Oriental Medicine, Dongshin University) ;
  • Kim Kyung-Soo (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Kyong-Yoo (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Lee In (Department of Herbology, College of Oriental Medicine, Wonkwang University)
  • 강성용 (동신대학교 한의과대학 본초학교실) ;
  • 김경수 (원광대학교 한의과대학) ;
  • 김경요 (원광대학교 한의과대학) ;
  • 이인 (원광대학교 한의과대학)
  • Published : 1998.11.30
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Abstract

The study was aimed to investigate the effect cuscutae semen(CS) on the vascular systems including changes in blood pressure (BP), regional cerebral blood flow(rCBF) and pial arteriolar diameter of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry, and the changes in diameter of pial arteriole were measured through a closed crainal window. 1. Blood pressure was not affected by CS in rats. 2. rCBF was increased by CS in a dose-dependent manner. 3. Pretreatment with methylene blue(Img/kg), and propranolol(1mg/kg) significantly inhibited CS induced increased in rCBF. 4. Pretreatment with indomethacin(1mg/kg) did not inhibited CS induced increased in rCBF. 5. Pial arterial diameter was increased by CS in a dose-dependent manner. These results suggest that CS causes a diverse response of blood pressure, regional cerebral blood flow(rCBF), and pial arteral diameter. The increased in rCBF is also mediated by adrenergic ${\beta}-receptor $ and guanylate cyclase.

Keywords

References

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