Journal of the korean academy of Pediatric Dentistry (대한소아치과학회지)
- Volume 25 Issue 2
- /
- Pages.335-351
- /
- 1998
- /
- 1226-8496(pISSN)
- /
- 2288-3819(eISSN)
EFFECTS OF AMYLASE ON THE DEMINERALIZATION IN HYDROXYAPATITE
Amylase가 Hydroxyapatite 탈회에 미치는 영향
- Lee, In-Hwan (Department of Pediatric Dentistry, Yonsei University) ;
- Seo, Jeong-Taeg (Oral Science Research Center, Yonsei University) ;
- Choi, Byung-Jai (Department of Pediatric Dentistry, Yonsei University) ;
- Lee, Jong-Gap (Department of Pediatric Dentistry, Yonsei University)
- 이인환 (연세대학교 치과대학 소아치과학교실) ;
- 서정택 (연세대학교 구강과학연구소) ;
- 최병재 (연세대학교 치과대학 소아치과학교실) ;
- 이종갑 (연세대학교 치과대학 소아치과학교실)
- Published : 1998.05.30
Abstract
Salivary proteins which are produced in the saliary acinar cells have been known to be involved in the Calcium and phosphate metabolism. The acquired pellicle resulting from such metabolism is considered as a secondary defence membrane against tooth caries. In this respect, some proteins included in saliva probably play an important role in the prevention of demineralization in enamel. On the other hand, fluoride has long been known to prevent the demineralization of enamel by the inhibition of the growth of Streptococcus mutans(S. mutans) and by the chemical reaction with calcium and phosphate, Therefore, I have examined the roles of amylase and albumin in the demineralization of enamel and compared these preteins with fluoride in terms of anticariogenic effect. 1. The demineralization caused by S. mutans occurred slowly and progressively for the first 60 min, then the rate of demineralization was accelerated afterwards. 2. pH decreased continuously during the entire period of each experiment. 3. The demineralization was significantly inhibited by the preteatment of amylase and fluoride but albumin had little effect on it. 4. An addition of 0.1 mM lactic acid (final concentration 0.1