Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Existence of Thermally Stable Thrombin Inhibitors in Soybean Paste, Doenjang

  • Kim, Dong-Chung (Department of Agricultural Chemistry, College of Agricultural and Life Sciences, Seoul National University,Korea Nutrition Research Institute, Korea University) ;
  • In, Man-Jin (Korea Nutrition Research Institute, Korea University) ;
  • Oh, Nam-Soon (Department of Food Science and Technology, Kongju National University) ;
  • Hwang, Woo-Ik (Korea Nutrition Research Institute, Korea University) ;
  • Jung, Jin (Department of Agricultural Chemistry, College of Agricultural and Life Sciences, Seoul National University)
  • Published : 1998.12.31
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Abstract

Antithrombotic function of doenjang was investigated using thoroughly desalted aqueous extract. In the presence of the extract, thrombin suffered loss of its fibrin-clotting activity, whose extent increased in a dose-dependent manner. The active substance involved in thrombin inhibition showed a high thermal stability. Results of Sephadex G-25 permeation chromatography indicated that there were at least two soluble thrombin inhibitors in doenjang with different molecular sizes.

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