Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Development of $LTD_4$ antagonists using QSAR

구조-활성간 연구를 통한 LTD4 antagonists의 개발

  • Oh, Min-A (Department of Applied Biology and Chemistry, Konkuk University) ;
  • Koh, Dong-Soo (Department of Applied Chemistry, Dongduk Women's University) ;
  • Park, Kwan-Ha (Department of Aquatic Pathology, Kunsan Nat'l. University) ;
  • Lee, Seung-Ho (Department of Pharmacology, Yeungnam University) ;
  • Lee, Hye-Seung (Department of Applied Biology and Chemistry, Konkuk University) ;
  • Lim, Yoong-Ho (Department of Applied Biology and Chemistry, Konkuk University)
  • 오민아 (건국대학교 응용생물화학과) ;
  • 고동수 (동덕여자대학교 응용화학과) ;
  • 박관하 (군산대학교 수족병리학과) ;
  • 이승호 (영남대학교 약학과) ;
  • 이혜승 (건국대학교 응용생물화학과) ;
  • 임융호 (건국대학교 응용생물화학과)
  • Published : 1998.10.31
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Abstract

In order to discover new Leukotriene $D_4$ antagonists, Quantitative Structure-Activity Relationships (QSAR) were applied based on the known data. A series of chalcone derivatives were selected for the training set. A candidate was predicted using QSAR and synthesized, and its biological activity was tested.

새로운 Leukotriene $D_4$ antagonists를 찾기 위해 구조-활성간 연구를 수행하였다. 이미 알려진 chalcone 유도체의 구조와 생물학적 활성 자료를 이용하여 구조-활성간 계산을 수행한 결과 새로운 화합물을 발견하였고, 이를 합성하여 효과를 측정한 결과를 보고하고자 한다.

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