Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Effect of Ainsliaea acerifolia Fraction Extract on Alcohol Dehydrogenase Activity

단풍취 분획물이 알콜대사효소에 미치는 영향

  • Zee, Ok-Pyo (Pharmacognocy Lab, Department of phramacy, Sungkyunkwan University) ;
  • Mun, Sae-Hun (Department of Food and nutrient, Chonnam National University) ;
  • Shin, Mal-Shick (Department of Food and nutrient, Chonnam National University) ;
  • Moon, Hyung-In (Pharmacognocy Lab, Department of phramacy, Sungkyunkwan University)
  • 지옥표 (성균관대학교 약학대학 생약학연구실) ;
  • 문세훈 (전남대학교 식품영양학과) ;
  • 신말식 (전남대학교 식품영양학과) ;
  • 문형인 (성균관대학교 약학대학 생약학연구실)
  • Published : 1998.10.31
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Abstract

Effects of organic solvents fraction from Ainsliaea acerifolia ethanol extract on alcohol metabolism in rats were examined and the results were as follows: Ethanol souble fraction, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic alcohol dehydrogenase(ADH) activity, on the other hand, the fraction insouble in ethanol was found to cause an increase ethanol concentration in the blood and inhibit ADH activity.

Spraque-Dawley계 수컷랫트에 계통분획한 단풍취의 각 분획물을 경구투여하고 혈청 ethanol농도와 간의 ADH활성에 미치는 효과를 검색 추적한 결과 알코올대사를 촉진시키는 성분은 주로 에탄올가용부에, 억제시키는 성분은 에탄올불용부에 주로 존재함을 추정할 수 있었고 현재 활성성분을 분리중에 있다.

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