Applied Biological Chemistry
- 제41권1호
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- Pages.99-103
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- 1998
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- 2468-0834(pISSN)
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- 2468-0842(eISSN)
새로운 Sulfonamide 유도체의 합성과 Acetolactate Synthase (ALS) 저해
Synthesis of Sulfonamide Derivatives as New Herbicidal Compounds and Studies on Biological Activity
- Chae, Jong-Kun (Department of chemistry, Seoul National University) ;
- Lee, Jae-Seob (Department of Biochemistry, Chungbuk National University) ;
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Choi, Jung-Do
(Department of Biochemistry, Chungbuk National University) ;
- Shin, Jung-Hyu (Department of chemistry, Seoul National University)
- 발행 : 1998.02.28
초록
Triazolopyrimidine sulfonanilide (TP) 유도체는 널리 사용되고 있는 제초제 중의 하나이다. 우리는 TP 유도체 화합물의 골격을 이루고 있는 벤젠 고리를 pyrimidine 고리로 치환시킨 새로운 3 종류의 sulfonamide 유도체(TPP)를 합성하고, 보리에서 추출한 acetolactate synthase (ALS)의 저해 활성도를 측정한 결과 0.005 부터 2 mM 사이의
Triazolopyrimidine sulfonanilide (TP) derivative is one of excellent herbicide compounds. We have synthesized three classes of a new sulfonamide derivative (TPP) as Acetolactate synthase (ALS) inhibitors, in which the benzene ring in TP skeleton was converted to substituted pyrimidyl ring and examined their inhibitory activities on barley for ALS.