Journal of Pharmaceutical Investigation
- 제28권3호
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- Pages.141-149
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- 1998
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
경피제제로서 수종의 플루비프로펜 Vehicle과 O/W 마이크로에멀젼의 평가
Evaluation or various vehicles and O/W Microemulsions of Flurbiprofen as Transdermal Delivery System
- Lee, Gye-Won (College of Pharmacy, Chungnam National University) ;
- Jee, Ung-Kil (College of Pharmacy, Chungnam National University)
- 발행 : 1998.09.20
초록
In order to reduce systemic side effects following administration, flurbiprofen was formulated as O/W microemulsion consisting of the surfactant, oil phase and aqueous phase. Particle size distribution, apparent viscosity, solubility and skin permeation of flurbiprofen in various vehicles and microemulsion were evaluated. The domain of O/W microemulsion s phase diagram had difference between oil types and the area of O/W microemulsion was wide distributed by adding to PG and cosurfactant than that of water alone. As increasing 10, 15 and 20% of Brij 97 content and 1, 2.5, 5% of oil content, the solubility of flurbiprofen in O/W microemulsions and various vehicles was