Journal of Pharmaceutical Investigation
- 제28권2호
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- Pages.93-98
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- 1998
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
안정성 및 Transfection 효율이 우수한 양이온성 리포좀 유전자 전달시스템의 개발
New Cationic Liposome with Enhanced Stability and Transfection Efficiency for Gene Delivery
- Kim, Kyoung-Mi (Institute of Pharmaceutical Research and Development, Wonkwang University) ;
- Nam, Bang-Hyun (College of Pharmacy, Wonkwang University) ;
- Sohn, Dong-Hwan (College of Pharmacy, Wonkwang University)
- 발행 : 1998.06.20
초록
We have developed liposomes which can be easily prepared with inexpensive lipid, have enhanced stability, and can efficiently deliver DNA into the COS-l cells, Liposome formulations were prepared using cationic materials such as dimethyldioctadecyl ammonium bromide (DDAB), cetyltrimethyl ammonium bromide(CTAB), We investigated the effect of cationic liposome formulations on in vitro DNA transfection, DDAB-containing liposomes showed increased transfection efficiency which was 3.2-fold as much as that by
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