생약학회지 (Korean Journal of Pharmacognosy)
- 제29권4호
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- Pages.379-383
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- 1998
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
팔진탕이 비소 중독된 흰쥐의 혈액에 미치는 영향
Effects of Paljin-Tang on the Blood of Arsenic-poisoned Rats
- Suh, Eun-Sil (College of Pharmacy, Woosuk University) ;
- Kim, Hoon (College of Pharmacy, Woosuk University) ;
- Lim, Jong-Pil (College of Pharmacy, Woosuk University)
- 발행 : 1998.12.30
초록
Sodium arsenate and Paljin-Tang extract (PJT), a herbal restorative were treated p.o. 20 mg/kg and 500 mg/kg, respectively, and concurrently to rats, and examined the biochemical parameters in blood. The values of white blood cell (WBC), red blood cell (RBC), hemoglobin (Hgb) and hematocrit (Hct) in each group did not show significant variance. The value of aspartate aminotrasferase(AST) of arsenic-treated group was increased for 2 weeks significantly while that of the group of concurrent administration with PJT became low significantly compared with arsenic-treated group and the value of alkaline phosphatase (ALP) of arsenic-treated group was decreased while that of the group of concurrent administration with PJT was increased significantly compared with arsenic-treated group. The value of glucose (Glu) was increased and those of lactic dehydrogenase (LDH), blood urea nitrogen (BUN) and triglyceride (TG) were decreased at first but increased later while the group of concurrent administration with PJT showed significant recovery from the toxicity of arsenic.