2,4-cis- and trans-isoannonacin: Cytotoxic Ketolactone Annonaceous Acetogenins from the Seeds of Asimina triloba

Asimina triloba 씨앗으로부터 세포독성 Annonaceous Acetogenin으로서의 2,4-cis- 및 trans-isoannonacin

  • Kim, Dal-Hwan (College of Pharmacy, Catholic University of Taegu-Hyosung) ;
  • Jung, Soon-Ja (College of Pharmacy, Catholic University of Taegu-Hyosung) ;
  • Kim, Chong-Won (College of Pharmacy, Catholic University of Taegu-Hyosung) ;
  • Woo, Mi-Hee (College of Pharmacy, Catholic University of Taegu-Hyosung)
  • 김달환 (대구효성가톨릭대학교 약학대학) ;
  • 정순자 (대구효성가톨릭대학교 약학대학) ;
  • 김종원 (대구효성가톨릭대학교 약학대학) ;
  • 우미희 (대구효성가톨릭대학교 약학대학)
  • Published : 1998.12.30

Abstract

Most Annonaceous acetogenins are potently bioactive and offer exciting potential as new antitumor, pesticidal and other bioactivites. The major mode of action of the acetogenin is inhibition of electron transport in the mitochodria. Two known cytotoxic ketolactone Annonaceous acetogenins, (2,4-cis)-isoannonacin (compound 1) and (2,4-trans)-isoannonacin (compound 2), have been isolated from Asimina triloba (Annonaceae) by bioactivity directed fractionation. The structures were characterized on the basis of chemical and spectral data. Compounds 1 and 2, which are known but are first isolated from the seeds of this species, were ob-tained. In brine shrimp lethality test (BST), 1 and 2 exhibited cytotoxicity.

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