생약학회지 (Korean Journal of Pharmacognosy)
- 제29권3호
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- Pages.248-253
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- 1998
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
박하의 항알레르기 활성
Antiallergic Activity of Menthae Herba
- Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
- Shin, Tae-Yong (College of Pharmacy, Woosuk University)
- 발행 : 1998.09.30
초록
Antiallergic activity of the aqueous extract of Menthae herba (MHAE) was investigated in mice and rats. MHAE inhibited systemic anaphylaxis induced by compound 48/80 in mice. Especially, MHAE inhibited compound 48/80 induced systemic anaphylaxis 100% with a dose of 500 mg/kg body weight. MHAE significantly inhibited serum histamine levels induced by compound 48/80. MHAE inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. Our studies provide evidence that MHAE will be beneficial in the treatment of anaphylaxis.