Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Biological Activities of Sesquiterpene Lactones isolated from Several Compositae Plants Part 1 - Cytotoxicity against Cancer Cell Lines -

수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제1보) - 암세포주에 대한 세포독성 -

  • Jang, Dae-Sik (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Park, Ki-Hun (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Kim, Hwan-Mook (Korea Research Institute of Bioscience & Biotechnology(KRIBB)) ;
  • Hong, Dong-Ho (Korea Research Institute of Bioscience & Biotechnology(KRIBB)) ;
  • Chun, Hyo-Kon (Korea Research Institute of Bioscience & Biotechnology(KRIBB)) ;
  • Kho, Yung-Hee (Korea Research Institute of Bioscience & Biotechnology(KRIBB)) ;
  • Yang, Min-Suk (Department of Agricultural Chemistry, Gyeongsang National University)
  • Published : 1998.09.30
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Abstract

A diverse panel of human tumor cell lines and a mouse melanoma cell line (B16-F1) were used for the cytotoxicity test of the nine sesquiterpene lactones with ${\beta}-methylene-{\gamma}-lactone$ group isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale. In the cell adhesion inhibitory activity test against B16-F1 mouse melanoma cell, hemistepcin B, cumambrin B, costunolide and tulipinolide were shown significant activities with $IC_{50}$ range of 2.2, 4.1, 0.9 and $0.3\;{\mu}g/ml$, respectively. In the cytotoxicity test against human tumor cells, the most active compound was costunolide having $IC_{50}$ values of below $0.3\;{\mu}g/ml$ against all the tested cell lines except for UACC62. Cumambrin A, hendelin and costunolide exhibited more strong activity against HCT15 and UO-31 cell lines than a positive control, adriamycin. All tested compounds showed an $IC_{50}$ values of below $5.0\;{\mu}g/ml$ against all the tested cell lines.

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