Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitory Activities of Korean Plants on HIV-1 Protease

  • Min, Byung-Sun (College of Pharmacy, Chungnam National University, Research Institute for Traditional Sino-Japanese Medicine, Toyama Medical and Pharmaceutical University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
  • Shimotohno, Kunitada (Virology Division, National Cancer Research Institute) ;
  • Miyashiro, Hirotsugu (Research Institute for Traditional Sino-Japanese Medicine, Toyama Medical and Pharmaceutical University) ;
  • Hattori, Masao (Research Institute for Traditional Sino-Japanese Medicine, Toyama Medical and Pharmaceutical University)
  • Published : 1998.12.01
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Abstract

For the development of anti-AIDS agents, thirty-seven methanol extracts of Korean plant materials were tested for their inhibitory effects on human immunodeficiency virus type-1 (HIV-1) protease. Extracts of seven plants showed more than 30% inhibitory activities on HIV-1 protease at a concentration of $100\;{\mu}g/ml$. The bark of Berchemia berchemiaefolia, the leaf of Lindera erythrocarpa and the whole plant of Siegesbeckia pubescens exhibited significant inhibititory activities on HIV-1 protease with 56.2, 50.8, and 46.6%, respectively.

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