The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Structure Elucidation of Minor Organic Constituents from Polyozellus multiflex

까치버섯 (Polyozellus multiflex)이 생산하는 미량 유기화합물의 화학구조

  • Hwang, Ji-Sook (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Ryu, Jong-Ha (Department of Agricultural Chemistry, Kyungpook National University) ;
  • Gu, Gyo-Cheol (Department of Agricultural Chemistry, Kyungpook National University) ;
  • Kwak, Ju-Yeon (Department of Agricultural Chemistry, Kyungpook National University) ;
  • Kim, Sang-In (Department of Agricultural Chemistry, Kyungpook National University) ;
  • Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Song, Kyung-Sik (Department of Agricultural Chemistry, Kyungpook National University)
  • 황지숙 (한국과학기술연구원 생명공학연구소) ;
  • 류종하 (경북대학교 농과대학 농화학과) ;
  • 구교철 (경북대학교 농과대학 농화학과) ;
  • 곽주연 (경북대학교 농과대학 농화학과) ;
  • 김상인 (경북대학교 농과대학 농화학과) ;
  • 유익동 (한국과학기술연구원 생명공학연구소) ;
  • 송경식 (경북대학교 농과대학 농화학과)
  • Published : 1998.12.30
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Abstract

Four minor compounds were isolated from fruiting bodies of Polyozellus multiflex by consecutive chromatographic separation. Their structures were identified as ergost-4,6,8,22-tetraen-3-one, 4-methoxy-6-methyl-2H-pyran-2-one, p-anisic acid, and p-hydroxybenzoic acid by spectral analysis. They could not inhibit prolyl endopeptidase nor acetylcholine esterase at the concentration up to 100 ppm.

국내 자생버섯인 까치버섯(Polyozellus multiflex의 메탄을 추출물로부터 이 버섯이 생산하는 2차 대사산물을 조사한 결과 기 보고된 주 2차 대사산물인 polyozellin 이외에 미량 2차 대사산물로서 4가지 화합물이 단리되었으며 이들은 각종 spectral analysis에 의하여 각각 ergost-4,6,8,22-tetraen-3-one, 4-methoxy-6-methyl-2H-pyran-2-one, p-anisic acid, 및 p-hydroxybenzoic acid로 동정되었다. 이들에 대하여 prolyl endopeptidase 및 acetylcholine esterase에 대한 저해 활성을 측정하였으나 최고 100 ppm의 농도에서도 저해활성을 나타내지 못하였다.

Keywords

References

  1. 한국균학회지 v.25 no.4 버섯중 항균활성물질개발 민지영;김은미;민태진
  2. Kor. J. Appl. Microbiol. Biotechnol. v.24 no.5 Polyozellus multiflex가 생산하는 지질과산화 저해물질 황지숙;송경식;김양섭;석순자;이태호;유익동
  3. 韓方で用ぃる藥用キノコ;キノコの化學,生化學 水野 卓;水野 卓(ed.);川合 正允(ed.)
  4. Z. Naturforsch v.39c New terphenylquinones from mycelial cultures of Punctularia atropurpurascens (Basidiomycetes)[1] Anke, H.
  5. Biochem. J. v.271 Slow tight-binding of prolyl endopeptidase by benzyloxycarbonylprolyl-prolinal Bakker, A.V.;Jung, S.;Spencer, R.;Vinick, F.J.;Faraci, W.S.
  6. Nature v.222 Inhibition of mouse Sarcoma 180 by polysaccharides from Lentinus edodes Chihara, G.;Maeda, Y.;Hamuro, J.;Sasaki, T.;Fukuoka, F.
  7. Biochem. Pharmacol. v.7 A new and rapid colorimetric determination of acetylcholinesterase activity Ellman, G.L.;Courtney, K.D.;Andres, V. Jr.;Featherstone, R.M.
  8. Phytochemistry v.36 no.1 Plant growth inhibiting apyrones from Alpinia speciosa Fujita, T.;Nishimura, H.;Kaburagi, K.;Muzutani, J.
  9. Arch. Pharm. Ber. Dtsch. Pharm. Ges. v.300 no.2 Components of Piper species. XIV. UVabsorption analysis of kawa lactones Haensel, R.;Langhammer, L.;Rimpler, H.
  10. Planta Med. v.51 Isolation and hypoglycemic activity of ganoderan A and B, glycans of Ganoderma lucidum fruit bodies Hikino, H.;Konno, C.;Mirin, Y.;Hayashi, T.
  11. J. Antibiotics v.50 no.9 Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiflex Hwang, J.S.;Song, K.S.;Kim, W.G.;Lee, T.H.;Koshino, H.;Yoo, I.D.
  12. Chem. Pharm. Bull. v.37 no.2 Ganoderic acid and its derivatives as cholesterol synthesis inhibitors Kamata, Y.;Shimizu, M.;Sonoda, Y.;Sato, Y.
  13. Tetrahedron v.28 no.4 Hypocholesterolemic alkaloids of Lentinus edodes. I;Structure and synthesis of eritadenine Kamiya, T.;Saito, Y.;Hashimoto, M.;Seki, H.
  14. Psyehopharmacologia v.18 no.1 Monoamines in the brain under the influence of muscimol and ibotenic acid, two psychoactive principles of Amanita musearia Konig-Bersin, P.;Waser, P.G.;Langemann, R.;Lichtensteiger, W.
  15. Tetrahedron Lett. no.5 Structure and synthesis of clitidine, a new pyridine nucleoside from Clitocybe acromelalga Konno, K.;Hayano, K.;Shirahama, R.;Saito, R.;Matsumoto, T.
  16. Planta-Med. v.63 no.4 Cytotoxic constituents from the stems of Diospyros maritima Kuo, Y.R.;Chang, C.I.;Li, S.Y.;Chou, C.J.;Chen, C.F.;Kuo, Y.H.;Lee, K.H.
  17. A new amino acid, (2S,3R)-(-)-3-hydroxybaikiain from Russula subnigrieans Kusano, G.;Ogawa, R.;Takahashi, A.;Nozoe, S.;Yokoyama, K.
  18. Gann v.66 Antitumor effect of protein-bound polysaccharide preparation, PS-K, against 3methylcholanthrene-induced fibrosarcoma in C57BL/6 mice Ohno, R.;Inmai, K.;Yokomaku, S.;Yamada, K.
  19. The library of $^{13}C\;and\;^1H$ FT-NMR spectra Pouchert, C.J.;Behnke, J.(eds.)
  20. J. Pharmaeobio-Dyn v.10 Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect Yoshimoto, T.;Kado, K.;Matsubara, F.;Koriyama, N.;Kaneto, H.;Tsuru, D.