The Korean Journal of Physiology and Pharmacology
- Volume 2 Issue 6
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- Pages.677-685
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Effects of Neonatal Footshock Stress on Glucocorticoid and $5-HT_{2A/2C}$ Receptor Bindings and Exploratory Behavior
- Kim, Dong-Goo (Department of Pharmacology and Yonsei Brain Research Institute, Yonsei University College of Medicine) ;
- Lee, Seoul (Department of Pharmacology and Yonsei Brain Research Institute, Yonsei University College of Medicine) ;
- Kang, Dong-Won (Department of Pharmacology, Kwandong University College of Medicine) ;
- Lim, Jong-Su (Department of Pharmacology and Yonsei Brain Research Institute, Yonsei University College of Medicine)
- Published : 1998.12.21
Abstract
To investigate the effects of neonatal stress on behavior and neurochemistry, rats were exposed to the footshock stress on postnatal day (PND) 14 or PNDs 14 and 21. Rats were exposed to uncontrollable electric shocks delivered to the floor with a constant current (0.8 mA) for 5 sec period. Daily sessions consisted of 60 trials on a random time schedule with an average of 55 sec. The first exposure to footshocks on PND 14 decreased body weight gain for 1 day. However, the second exposure to footshocks on PND 21 did not affect body weight gain. Exploratory activity was measured by exposing a rat to a novel environment 24 h after experience of footshocks. Similar to the body weight changes, a decreased activity was noted after the first exposure to footshocks, while no changed activity was noted after the second exposure to footshocks. However, the Bmax value of