소소식청울탕(消消食淸鬱湯)이 부자독성(附子毒性)으로 유발(誘發)된 흰쥐의 간조직(肝組織)에 미치는 영향(影響)

The Effect of SoSikCheongWool-Tang on White Rats' Hepatocyte Damages Induced by Radix Aconitine

The purpose of this study is to investigate the effect of SoSikCheongWool-Tang on white rats' hepatocyte damages induced by Radix Aconitine. For the study, Radix Aconitine was administered to white rats, damaging their hepatocytes, and then SoSikCheongWool-Tang was given to the rats. As a result, the following histological changes of the hepatocytes were observed through light and electron microscope: 1. Radix Aconitine damaged the congestion, necrosis and hemolysis in the liver. 2. In the six-hour control group, the cisternae of rough and smooth endoplasmic reticula were dilated or disoriented, and the attached ribosomes of rough endoplasmic reticulum were hardly observed. 3. In the three-day control group, the destruction of the nucleus as well as the damage of all the cell-organelles was observed. 4. In all the experiment groups, the rats, after given SoSikCheongWool-Tang, quickly recovered from the cytotoxicity induced by aconitine extracts. From the above results, this study has come to the conclusion that SoSikCheongWool-Tang is efficacious against the cytotoxicity induced by Radix Aconitine.