Journal of the Korean Wood Science and Technology

The Korean Society of Wood Science & Technology (한국목재공학회)
권호 표지

Analysis of Cytotoxic Constituent of Berberis koreana Palibin

매자나무 세포독성성분 분석

  • Kim, Young-Kyoon (Department of Forest Products, College of Forest Science, Kookmin University) ;
  • Kwak, Byung-Man (Department of Forest Products, College of Forest Science, Kookmin University)
  • 김영균 (국민대학교 삼림과학대학 임산공학과) ;
  • 곽병만 (국민대학교 삼림과학대학 임산공학과)
  • Received : 1998.07.20
  • Published : 1998.09.30
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Abstract

Methanol extracts of five Berberidaceae species were examined against tissue factor inhibitory and tumour cell growth inhibitory activity. Methanol extracts of Berberis koreana Palibin showed a strong cytotoxicity activity against SK-MEL-2 (Melanoma) tumour cell lines with more than 90% in $25{\mu}g/m\ell$ and against A549 (Lung carcinoma), SK-OV-3 (Ovarian cancer), XF498 (CNS cancer) and HCTl5 (Colon cancer), other Berberidaceae species except B. koreana species have no effect on the tumour cells. Biologically active compound, therefore, was isolated through the activity guided fractionation and purification. The structure was confirmed by NMR. FT-IR and MS to 2-(3,4-dihydroxybenzyl)-ethyl alcohol. It showed cytotoxicity activity against SNU-C4 tumour cell lines with 50.7% in $50{\mu}g/m\ell$. Methanol extracts of 5 Berberidacae species have no effect on the tissue factor inhibitory activity.

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Acknowledgement

Supported by : 한국과학재단