Clinical and Experimental Reproductive Medicine
- 제24권1호
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- Pages.119-133
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- 1997
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
체외수정시술시 배아의 보조부화술을 이용한 임신율 향상에 관한 연구
Improvement of Pregnancy Rate by Assisted Hatching of Human Embryos in In Vitro Fertilization and Embryo Transfer Program
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김석현
(서울대학교 의과대학 산부인과학교실) ;
- 김광례 (서울대학교 의과대학 산부인과학교실) ;
- 채희동 (서울대학교 의과대학 산부인과학교실) ;
- 이재훈 (서울대학교 의과대학 산부인과학교실) ;
- 김희선 (서울대학교 의과대학 산부인과학교실) ;
-
류범용
(서울대학교 의과대학 산부인과학교실) ;
- 오선경 (서울대학교 의과대학 산부인과학교실) ;
- 서창석 (서울대학교 의과대학 산부인과학교실) ;
-
최영민
(서울대학교 의과대학 산부인과학교실) ;
-
김정구
(서울대학교 의과대학 산부인과학교실) ;
- 문신용 (서울대학교 의과대학 산부인과학교실) ;
-
이진용
(서울대학교 의과대학 산부인과학교실)
-
Kim, Seok-Hyun
(Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Kim, Kwang-Rye (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Chae, Hee-Dong (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Lee, Jae-Hoon (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Kim, Hee-Sun (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
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Ryu, Buom-Yong
(Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Oh, Sun-Kyung (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Suh, Chang-Suk (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
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Choi, Young-Min
(Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
-
Kim, Jung-Gu
(Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Moon, Shin-Yong (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
-
Lee, Jin-Yong
(Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
- 발행 : 1997.04.30
초록
In spite of much progress in vitro fertilization and embryo transfer (IVF-ET) program, the pregnancy rate remains at 20-30%, and the endometrial implantation rate per embryo transferred at 10-15%. As a result, about 90% of embryos may fail to implant to the endometrium, and many attempts such as optimization of follicular development, improvement of in vitro culture system including coculture, and micromanipulation of zona pellucida have been made to improve embryonic implantation after IVF-ET. Recently, several procedures of assisted hatching (AH) using micromanipulation have been introduced, and pregnancies and births have been obtained after AH. To develop and establish AH as an effective procedure to improve embryonic implantation, AH with partial zona dissection (PZD) was performed in 116 cycles of 89 infertile couples who had previous repeated failures of standard IVF-ET more than two times (Group I: 71 cycles in 54 patients), or who had implantation failure of embryos with good quality (Group II: 15 cycles in 13), or who had undergone AH without specific indication (Group III: 30 cycles in 22) from January, 1995 to Februry, 1996, and the outcomes of AH were analyzed according to pregnancy rate. The number of oocytes retrieved after controlled ovarian hyperstimulation (COH) was
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