Clinical and Experimental Reproductive Medicine
- Volume 24 Issue 1
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- Pages.101-109
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- 1997
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
Fertilization and Pregnancy Rate of Testicular Sperm after Testicular Sperm Extraction (TESE) with Intracytoplasmic Sperm Injection(ICSI)
고환조직 정자채취술과 세포질내 정자주입술을 이용한 고환조직 정자의 수정률과 임신율
-
Park, Yong-Seog
(Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center) ;
- Seo, Ju-Tae (Department of Urology, Samsung Cheil Hospital & Women's Healthcare Center) ;
- Jun, Jin-Hyun (Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center) ;
- Byun, Hye-Kyung (Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center) ;
- Kim, Jong-Hyun (Department of Urology, Samsung Cheil Hospital & Women's Healthcare Center) ;
- Lee, You-Sik (Department of Urology, Samsung Cheil Hospital & Women's Healthcare Center) ;
- Son, Il-Pyo (Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center) ;
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Kang, Inn-Soo
(Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center) ;
- Lee, Ho-Joon (Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center)
-
박용석
(삼성제일병원 불임연구실) ;
- 서주태 (삼성제일병원 비뇨기과) ;
- 전진현 (삼성제일병원 불임연구실) ;
- 변혜경 (삼성제일병원 불임연구실) ;
- 김종현 (삼성제일병원 비뇨기과) ;
- 이유식 (삼성제일병원 비뇨기과) ;
- 손일표 (삼성제일병원 산부인과) ;
-
강인수
(삼성제일병원 산부인과) ;
- 이호준 (삼성제일병원 불임연구실)
- Published : 1997.04.30
Abstract
This study was carried to determine the possibility of finding motile spermatozoa and fertilization, pregnancy rate after testicular sperm extraction(TESE) with ICSI in obstructive and non-obstructive azoospermic patients. In 154 cases(132 patients), obstructive azoospermia was 77 cases and non-obstructive azoospermia was 77 cases. In obstructive azoospermia, patients generally showed normal spermatogenesis and included vas agenesis(n=8), multiple vas obstruction(n=7), epididymal obstruction (n=54). Total of 982 retrieved oocytes were obtained and 84.4% were injected. The fertilization rates with 2 PN and cleavage rate were 72.5% and 62.3%, respectively. 30 pregnancies(38.9%) were achieved and the ongoing pregnancies were 22 cases (28.6%). In non-obstructive azoospermia, patients showed hypospermatogenesis(n=49), maturation arrest(n=4), Sertoli cell only syndrome (n=24). The various stages of spermatogenic cell could be retrieved by TESE and could be reached normal fertilization and embryo development with ICSI. Total of 1072 retrieved oocytes obtained and 80.2% were injected. The fertilization rates with 2 PN and cleavage rate were 52.8% and 68.9%, respectively. 22 pregnancies(30.1%) were achieved and the ongoing pregnancies were 19 cases(26.0%). Conclusively, the combination of TESE with ICSI using testicular spermatozoa can achieve normal fertilization and pregnancy rate and effective method in obstructive and non-obstructive azoospermic patients.