Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Hantavirus Pulmonary Syndrome

한타바이러스 폐 증후군

  • Lee, Kye-Young (Department of Internal Medicine, College of Medicine Dan Kook University) ;
  • Kim, Yun-Seup (Department of Internal Medicine, College of Medicine Dan Kook University) ;
  • Jee, Young-Koo (Department of Internal Medicine, College of Medicine Dan Kook University) ;
  • Bai, Hyun-Ju (Department of Internal Medicine, College of Medicine Dan Kook University) ;
  • Yun, Sung-Cheul (Department of Internal Medicine, College of Medicine Dan Kook University) ;
  • Kim, Keun-Youl (Department of Internal Medicine, College of Medicine Dan Kook University)
  • 이계영 (단국대학교 의과대학 내과학교실) ;
  • 김윤섭 (단국대학교 의과대학 내과학교실) ;
  • 지영구 (단국대학교 의과대학 내과학교실) ;
  • 배현주 (단국대학교 의과대학 내과학교실) ;
  • 윤성철 (단국대학교 의과대학 내과학교실) ;
  • 김건열 (단국대학교 의과대학 내과학교실)
  • Published : 1997.12.31
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Abstract

Hantavirus pulmonary syndrome(HPS) is a systemic disease that is caused by a newly discorved and characterized virus of the Hantavirus genus, which is most frequently referred to as the sin nombre virus. The clinical syndrome resembles other hantavirus syndromes worldwide, except that it is characterized by a brief prodromal illness followed by rapidly progressive, noncardiogenic edema, and that it is more deadly than any previously recognized hantavirus infection. The clinical manifestations of HPS are characterized by four clinical phases : prodrome, pulmonary edema and shock, diuresis, and convalescence. Mortality is greatest in the first 24 hours of the pulmonary edema and shock phase of the illness. These phases are strikingly similar to the clinical phases of Hemorrhagic fever with renal syndrome(HFRS) induced by Hantaan virus, except that HPS has not been associated with renal failure and Disseminated intravascular coagulation(DIC). We here report a case of hantavirus pulmonary syndrome developed in a 58 year-old man. He had a flu-like illness followed by the rapid onset of respiratory failure due to noncardiogenic pulmonary edema. HPS was diagnosed by clinical manifestations, identification of high titer antibody to Hantaan virus antigen and histologic finding of transbronchial lung biopsy (TBLB) specimen. The patient was treated with mechanical ventilation and initial corticosteroid pulse therapy resulting in successful outcome.

저자들은 감기증상 후에 빠른 시간내에 급성호흡부전증에 이르렀던 환자에서 신증후성 출혈열과는 다르게 주로 호흡기와 순환기를 침범하는 한타바이러스 폐 증후군 1예률 경험하였기에 고하는 바이다.

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