Tuberculosis and Respiratory Diseases
- 제44권2호
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- Pages.338-348
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- 1997
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
말초혈액 단핵구에 대한 내독소 자극의 신호 전달에서 Protein Kinase C와 Protein Tyrosine Kinase의 역할
The Role of Protein Kinase C and Protein Tyrosine Kinase in the Signal Transduction Pathway of Stimulus Induced by Endotoxin in Peripheral Blood Monocyte
- 김재열 (서울대학교 의과대학 내과학교실 및 폐연구소) ;
- 박재석 (단국대학교 의과대학 내과학 교실) ;
- 이귀래 (한국보훈병원) ;
- 유철규 (서울대학교 의과대학 내과학교실 및 폐연구소) ;
- 김영환 (서울대학교 의과대학 내과학교실 및 폐연구소) ;
- 한성구 (서울대학교 의과대학 내과학교실 및 폐연구소) ;
- 심영수 (서울대학교 의과대학 내과학교실 및 폐연구소)
- Kim, Jae-Yeol (Department of Internal Medicine and Lung Research Institute, Seoul National University College of Medicine) ;
- Park, Jae-Suk (Deportment of Internal Medicine Dankook University Conege of Medicine) ;
- Lee, Gwi-Lae (Korea Veterans Hospital) ;
- Yoo, Chul-Gyu (Department of Internal Medicine and Lung Research Institute, Seoul National University College of Medicine) ;
- Kim, Young-Whan (Department of Internal Medicine and Lung Research Institute, Seoul National University College of Medicine) ;
- Han, Sung-Koo (Department of Internal Medicine and Lung Research Institute, Seoul National University College of Medicine) ;
- Shim, Young-Soo (Department of Internal Medicine and Lung Research Institute, Seoul National University College of Medicine)
- 발행 : 1997.04.30
초록
Background : Endotoxin, the component of outermembrane of gram negative organism, plays an important role in the initiation and amplification of inflammatory reaction by its effects on inflammatory cells. Until recently, there have been continuing efforts to delinate the mechanisms of the signal trasduction pathway of endotoxin stimuli on inflammatory cells. By uncovering the mechanisms of signal transduction pathway of endotoxin stimuli, we can expect to have tools to control the excessive inflammatory responses which sometimes may be fatal to the involved host. It was generally accepted that endotoxin exerts its inflammatory effects through inflammatory cytokines that are produced by endotoxin-stimulated inflammatory cells and there were some reports on the importance of protein kinase C and protein tyrosine kinase activation in the production of inflammatory cytokines by endotoxin So we evaluated the effect of pretreatment of protein kinase C inhibitors (H7, Staurosporin) and protein tyrosine kinase inhibitors(Herbimycin, Genistein) on the endotoxin-stimulated cytokines(IL-8 & TNF-