Continuous Antiemetic Effects of Single Intravenous Injection of Antiemetics during Postoperative Pain Control with Morphine

Morphine 정주를 이용한 술후 통증 조절시 진토제 일회 정주의 지속적 항오심 및 항구토 효과

  • Choi, Gi-Sun (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • An, Chi-Hong (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Park, Sung-Sik (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Lim, Dong-Geon (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Baek, Woon-Yi (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Park, Jin-Woong (Department of Anesthesiology, School of Medicine, Kyungpook National University)
  • 최기선 (경북대학교 의과대학 마취과학교실) ;
  • 안치홍 (경북대학교 의과대학 마취과학교실) ;
  • 박성식 (경북대학교 의과대학 마취과학교실) ;
  • 임동건 (경북대학교 의과대학 마취과학교실) ;
  • 백운이 (경북대학교 의과대학 마취과학교실) ;
  • 박진웅 (경북대학교 의과대학 마취과학교실)
  • Published : 1997.05.31

Abstract

Background : This study was designed to evaluate the continuous effects of single intravenous injection of antiemetics on nausea and vomiting during continuous morphine injection for postoperative pain control. Methods : Prior to the study, we divided patients into two major groups according to the type of surgery performed intra-abdominal(Open: O) and non intra-abdominal(Close: C). When patients regained orientation after routine general anesthesia, enflurane-$O_2-N_2O$, we injected bolus dose of morphine and started continuous injection of morphine for postoperative pain control(Group I; Control). After bolus injection and just before continuous injection, we injected single dose of droperidol(Group II) or ondansetron(Group III). Mean arterial blood pressure, heart rate, pain score and symptom-therapy score were checked at 10 minutes, 4, 8, 16, 24, 36 hours after continuous morphine injection. Results : The pain score of group III was lower than group II(10 min.) and group I(24, 36 hours) in the open group. Symptom-therapy score of group III(10 min., 4, 24 hours) and group II(10 min.) were lower than group I in the open group. In the close group, symptom-therapy score of group III(8 hours) was lower than group I. Conclusions : Single intravenous injection of antiemetics have a tendency of lowering symptom-therapy score for 36 hours in spite of their relatively short elimination half-life.

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