Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Effect of the Seaweed (Monostroma nitidum) Extract on Triton WR-1339 Induced Hyperlipidemia in Mouse

Triton WR-1339 복강주사로 유도된 생쥐의 고지혈증에 대한 참홑파래 추출물의 영향

  • JUNG Yeongha (Dept. of Marine Biology, Pukyong National University) ;
  • CHO Yong-Chul (Department of Aquaculture, National Fisheries Research and Development Institute) ;
  • PARK In-Sick (Department of Anatomy, College of Oriental Medicine, Dongguk University) ;
  • AHN Sang-Hyun (Department of Anatomy, College of Oriental Medicine, Dongguk University) ;
  • KIM Jin-Taek (Department of Anatomy, College of Oriental Medicine, Dongguk University) ;
  • KANG Yong-Joo (Dept. of Marine Biology, Pukyong National University) ;
  • HONG Yong-Ki (Dept. of Biotechnology, Pukyong National University)
  • 정영하 (부경대학교 해양생물학과) ;
  • 조용철 (수산진흥원 남해수산연구소 증식과) ;
  • 박인식 (동국대학교 한의과대학 해부학교실) ;
  • 안상현 (동국대학교 한의과대학 해부학교실) ;
  • 김진택 (동국대학교 한의과대학 해부학교실) ;
  • 강용주 (부경대학교 해양생물학과) ;
  • 홍용기 (부경대학교 생물공학과)
  • Published : 1997.09.01
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Abstract

An antihyperlipidemic effect was observed by intraperitoneal injection of the seaweed Monostroma nitidum extract. Hyperlipidemia was induced by intraperitoneal injection of Triton WR-1339 $(60\;{\mu}g/g-body\;weight)$ into a mouse. Maximum level of blood cholesterol was reached at 20 hours after Triton injection. By simultaneous injection of the M. nitidum extract $(30\;{\mu}g/g-body\;weight)$ with the Triton into each right and left sides of the peritoneal cavity, levels of total cholesterol and low density lipoprotein were decreased to $24\%\;and\;14\%$ compared to Triton injection only. For histochemical changes, hepatic tissues obtained at 40 hours after injection of the Triton and the M. nitidum extract were fixed in fromol-calcium solution. The meshlike cytoplasms disappeared and hapatic plates were recovered in mice injected with the M. nitidum extract. Numbers of lipid drops and cholesterol particles also decreased in the portal space of the hepatic cytoplasm. This indicates that the accumulation of lipid, including cholesterol, caused by Triton was prevented by the antihyperlipidemic effect of extract from the seaweed M. nitidum.

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