Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Study on the Skin Absorption of the Organic Solvents

유기용제의 피부흡수 연구

  • Kim, Hyeon-Yeong (Industrial Chemical Research Center, Korea Industrial Safety Corporation, Industrial Health Research Institute) ;
  • Chung, Yeong-Hyen (Industrial Chemical Research Center, Korea Industrial Safety Corporation, Industrial Health Research Institute) ;
  • Jeong, Jae-Hwang (Industrial Chemical Research Center, Korea Industrial Safety Corporation, Industrial Health Research Institute) ;
  • Sur, Gil-Soo (Department of Chemical Engineering, Yeungnam University) ;
  • Moon, Young-Han (Industrial Chemical Research Center, Korea Industrial Safety Corporation, Industrial Health Research Institute)
  • 김현영 (한국산업안전공단 산업보건연구원) ;
  • 정용현 (한국산업안전공단 산업보건연구원) ;
  • 정재황 (한국산업안전공단 산업보건연구원) ;
  • 서길수 (영남대학교 공과대학 화학공학과) ;
  • 문영한 (한국산업안전공단 산업보건연구원)
  • Published : 1997.11.13
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Abstract

The penetrating speeds of organic solvents into the nude mouse skin were measured by in vitro methods(diffusion cell methods) and in vivo methods(measuring internal residues of the organic solvents). The results were as follows: 1. The penetrating speeds of toluene, m-xylene, MEK, MIBK, ethanol, IPA and 2-bromopropane into the skin were $0.4832mg/cm^2/h$, $0.1738mg/cm^2/h$, $1.124mg/cm^2/h$, $0.6627mg/cm^2/h$, $1.747mg/cm^2/h$, $1.359mg/cm^2/h$, and 2-bromopropane $4.165mg/cm^2/h$ respectively. 2. The penetrating speeds of the mixtures of two, toluene and m-xylene, the mixture of three, IPA, ethyl acetate, and MIBK, the mixture of five, toluene, m-xylene, IPA, ethyl acetate, and MIBK were $0.172mg/cm^2/h$, $1.431mg/cm^2/h$, and $2.983mg/cm^2/h$ respectively. 3. The absorption speeds of 2-bromopropane and styrene which were measured by in vivo processes were $3.12mg/cm^2/h$ and $1.44mg/cm^2/h$ respectively. The absorption speed of 2-bromopropane mesured in vivo was 74.9% of that measured by in vitro methods, $4.165mg/cm^2/h$.

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