YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Pharmacological Actions of New Woohwangchungsimwon Pill on Cerebral Ischemia and Central Nervous System

신우황청심원의 뇌허혈 및 중추신경계에 대한 약효

  • Cho, Tai-Soon (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Sun-Mee (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Cho, Sung-Ig (Natural Products Research Institute, Seoul National University) ;
  • Kim, Yong-Kee (Institute of Life Science Research, Cho Seon Pharm. & Trading Co., Ltd.) ;
  • Shin, Dae-Hee (Institute of Life Science Research, Cho Seon Pharm. & Trading Co., Ltd.) ;
  • Park, Dai-Kyu (Institute of Life Science Research, Cho Seon Pharm. & Trading Co., Ltd.)
  • 조태순 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 조성익 (서울대학교 천연물과학연구소) ;
  • 김용기 (조선무약(자) 생명과학연구소) ;
  • 신대희 (조선무약(자) 생명과학연구소) ;
  • 박대규 (조선무약(자) 생명과학연구소)
  • Published : 1997.12.01
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Abstract

In order to investigate pharmacological properties of New Woohwangchungsimwon Pill (NWCH) and Woohwangchungsimwon Pill(WCH), effects of NWCH and WCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in Mongolian gerbils. The histological observations showed preventive effect of NWCH and WCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by NWCH and WCH treatment. In contrast to what was seen with ATP, the lactate and lipid peroxide were both elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NWCH and WCH treatments. In central nervous system, NWCH and WCH had sedative effect in rotarod and spontaneous activity test, but no effects on the hexobarbital-induced sleeping time. And, NWCH and WCH had weak anticonvulsion effects in electric shock- and pentetrazol-induced convulsion test. NWCH and WCH increased the respiration rate, but decreased the respiration depth in rats. Furthermore, NWCH and WCH showed antistress effect. Our findings suggest that the pharmacological profiles of NWCH on cerebral ischemia and central nervous system are similar to that of WCH.

Keywords

References

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