YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Pharmacological Actions of New Woohwangchungsimwon Pill on Cardiovascular System

신우황청심원의 심혈관계에 대한 약효

  • Cho, Tai-Soon (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Sun-Mee (College of Pharmacy, Sung Kyun Kwan University) ;
  • Kim, Nak-Doo (College of Pharmacy, Seoul National University) ;
  • Huh, In-Hoi (College of Pharmacy, Chung Ang University) ;
  • Ann, Hyung-Soo (College of Pharmacy, Dongduck Women's University) ;
  • Kwon, Kwang-Il (College of Pharmacy, Chungnam National University) ;
  • Park, Seok-Ki (Institute of Life Science Research, Cho Seon Pharm. & Trading Co., Ltd.) ;
  • Shim, Sang-Ho (Institute of Life Science Research, Cho Seon Pharm. & Trading Co., Ltd.) ;
  • Shin, Dae-Hee (Institute of Life Science Research, Cho Seon Pharm. & Trading Co., Ltd.) ;
  • Park, Dai-Kyu (Institute of Life Science Research, Cho Seon Pharm. & Trading Co., Ltd.)
  • 조태순 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 김낙두 (서울대학교 약학대학) ;
  • 허인희 (중앙대학교 약학대학) ;
  • 안형수 (동덕여자대학교 약학대학) ;
  • 권광일 (충남대학교 약학대학) ;
  • 박석기 (조선무약(자) 생명과학연구소) ;
  • 심상호 (조선무약(자) 생명과학연구소) ;
  • 신대희 (조선무약(자) 생명과학연구소) ;
  • 박대규 (조선무약(자) 생명과학연구소)
  • Published : 1997.12.01
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Abstract

In order to investigate the pharmacological properties of New Woohwangehungsimwon Pill (NWCH). Effects of Woohwangehungsimwon Pill (WCH) and NWCH were compared using various experimental models. In isolated rat aorta, NWCH and WCH showed the relaxation of blood vessels in maximum contractile response to phenylephrine ($10^{-6}$M) without regard to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not affect significantly the relaxative effects of NWCH and WCH. NWCH and WCH inhibited the vascular contractions induced by acethylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats(SHRs), NWCH and WCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, these had no effects on parameters of action potential at low doses, whereas inhibited the cardiac, contractility at high doses. Furthermore, these had a significant inhibitory effects on heart acceleration in normotensive rats and SHRs. These results suggested that NWCH and WCH have weak cardiovascular effects, and that there is no significant differences between two preparations.

Keywords

References

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