YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of p-(Acetylamino)phenylacetic acid As an Antirheumatic Agent

항류우머티즘 물질인 p-(아세틸아미노)페닐아세트산의 합성

  • Published : 1997.08.01
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Abstract

The efficient synthesis of p-(acetylamino)phenylacetic acid(7), a antirheumatic agent, is reported. Methyl phenylacetate(3) was prepared from Friedel- Crafts reaction of benzene with methyl ${\alpha}$-chloro-${\alpha}$-(methylthio)acetate(1) followed by reductive desulfurization with zinc dust in acetic acid. Compound(7) was obtained from 3 by a sequence of nitration, reduction, N-acylation, and hydrolysis.

Keywords

References

  1. Pharmaceutical Chemistry(Drug Sunthesis) Vol. 1 Roth, H.J.;Kleeman, A.
  2. Arch. Pharm. Res. v.17 Synthesis of 2-(2-fluorenyl)propanoic acid Choi, H.D.;Geum, D.H.;Kowak, Y.S.;Son, B.W.
  3. Yakhak Hoeji v.38 Synthesis of 2-aryl-5-benzoxzolepropionic acid dericatives as antiinflammatory agent Choi, H.D.;Kowak, Y.S.;Geum, D.H.;Son, B.W.
  4. Arch. Pharm. Res. v.19 Synthesis of 4-(2-Thiazolyloxy)phenylalkanoic acids as an antiinflammatory agent Choi, H.D.;Shin, S.H.;Son, B.W.
  5. Drugs. Fur. v.14 (Japan)and Nippon Shinyaku Co. Ltd.(Japan)::p-(Acetylamino)phenylacetic acid Mitsubishi Chem. Co. Ltd.
  6. Drugs. Fur. v.16 (Japan)and Nippon Shinyaku Co. Ltd.(Japan): Actarit(MS-932) Mitsubishi Chem. Ind. Co. Ltd.
  7. Dictionary of Organic Compounds Vol. 4 Buckingham, J.;Donaghy, S.M.
  8. Arch. Pharm. Res. v.16 Synthesis of 7-[p-(methylthio)benzoyl]-5-benzenefuranacetic acid Choi, H.D.;Geum, D.H.;Kowak, Y.S.;Son, B.W.