약학회지 (YAKHAK HOEJI)

  • 제41권4호
  • /
  • Pages.433-438
  • /
  • 1997
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  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

곰팡이 분리주 No. 51005로부터 포스포리파제 C 저해물질 앙길로스포랄의 분리

Isolation of Anguillosporal, a Potent Inhibitor of Phospholipase C from Fungi Isolate No. 51005

  • 오원근 (생명공학연구소, 세포반응조절 연구Unit) ;
  • 이현선 (생명공학연구소, 세포반응조절 연구Unit) ;
  • 안순철 (생명공학연구소, 세포반응조절 연구Unit) ;
  • 고학룡 (생명공학연구소, 세포반응조절 연구Unit) ;
  • 김보연 (생명공학연구소, 세포반응조절 연구Unit) ;
  • 민태익 (생명공학연구소, 세포반응조절 연구Unit) ;
  • 안종석 (생명공학연구소, 세포반응조절 연구Unit)
  • Oh, Won-Keun (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyun-Sun (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ahn, Soon-Cheol (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ko, Hack-Ryong (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Bo-Yeon (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Min, Tae-Ick (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ahn, Jong-Seog (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology)
  • 발행 : 1997.08.01
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초록

MT 51005 as a potent inhibitor of phospholipase C(PLC) was purified from the culture broth of a fungal strain No. 51005 isolated from soil. It was identified as a benzaldehyde d erivative, anguillosporal. by the physico-chemical properties and spectroscopic data. Anguillosporal showed the inhibitory activity against purified PLC with an $IC_{50}\;of\;13{\mu}g/ml$. And it also inhibited the formation of inositol phosphates($IP_t$) in platelet-derived growth factor(PDGF)-stimulated $NIH3T3{\gamma}1$ cells with an $IC_{50}\;of\;0.8{\mu}g/ml$.

키워드

참고문헌

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