약학회지 (YAKHAK HOEJI)

  • 제41권2호
  • /
  • Pages.181-186
  • /
  • 1997
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

7-데아자하이포크산틴과 7-데아자아데닌 유도체의 합성

Synthesis of 7-Deazahypoxanthine and 7-Deazaadenine Derivatives

  • Sin, Kwan-Seog (College of Pharmacy, Kangwon National University) ;
  • Kim, Nam-Ho (College of Pharmacy, Kangwon National University) ;
  • Lee, Joo-Heon (College of Pharmacy, Kangwon National University) ;
  • Sung, Sun-Young (College of Pharmacy, Kangwon National University) ;
  • Pachaly, Peter (Pharmazeutisches Institut der Universitaet Bonn)
  • 발행 : 1997.04.01
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초록

A series of 7-deazahypoxanthine and 7-deazaadenine derivatives[6,7.8.9.10,13] as purine antagonists was prepared. The pyrrolidine-5-one derivatives[4,11] were treated vith $(C_2H_5)_3OBF_4$ to give 3- aryl-5-ethoxy-2H-3,4-dihydropyrrole[5,12], which were converted to 7-aryl-7,8-dihydro-7(9H)-deazahy-poxanthine[6,7,8,9,10] and 7-phenyl-2-methyl-7,8- dihydro-7(9H)-deazaadenine[13].

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참고문헌

  1. J. Antibioticts(Tokyo) v.9A Antibiotic substance extracted from the culture filtrate and mycelium of Streptomyces toyocaensis Nishimura, H.;Katakiri, K.;Sato, K.;Mayama, M.;Shimaoka, N.
  2. J. Antibiotics(Tokyo) v.10A Antibiotic substance produced in the culture broth of streptomyces tubericidus Anzai, K.;Nakamura, G.;Suzuki, S.
  3. J. Am. Chem. Soc. v.90 pyrrole[2.3-d] pyrimidine nucleoside antibiotics. Total synthesis and structure of Toyocamycin, Unamycin B. Vengicide. Antibiotic E-212, and sangivamycin(BA-90912) Tolman, R. L.;Robinsons, R. K.;Townsend. L. B.
  4. J. Am. Chem. Soc. v.91 Pyrrolepyrimidine nucleosides. Ⅲ. The total synthesis and structure of Toyocamycin. sangimycin, Tubercidin and related derivatives Tolman, R. L.;Robisons, R. K.;Townsend, L. B.
  5. Synthesis v.101 phosphorus pentaoxide in organic synthesis. ⅩⅠ. A new synthesis approach to 7-deazahy-poxanthines Girgis, N.;Joergensen, A.;Pedersen, E. B.
  6. Chem. Scr. v.25 Phosphorus pentaoxide in organic synthesis. ⅩⅩⅠ: synthesis of 7H-pyrrolo[2,3-d]pyrimidine-a93H)-ones and N-aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines Joergensen, A.;El-bayouki;Khairy, A. M.
  7. Liebigs Ann. Chem. A purine/deaza-purine dinucleoside monophosphate containing 2-amino-7H-pyrrolo[2,3-d]pyrimidine as fluorescent base Seela, F.;Engelk, U.
  8. Biochemistry v.24 Oliomers with alternating thymidine and 2'-deoxytubercidine: duplex stabilization by a 7-deazapurine base Seela, F.;Kehne, A.
  9. Liebigs Ann. Chem. synthesis of 7-deaza-2', 3'-dideoxyguanosine by deoxygenation of its 2'-deoxy-β-D-ribofuranoside Seela, F.;Muth, H. P.
  10. J. Heterocycl. Chem v.23 Amino acids as bifunctional synthons of pyrrol[1,2-a]-and -[2,3-d]annelated heterobicycles Sinambela, J. M.;Zimmermann, W,;Roth, H. J.;Eger, K.
  11. Liebigs Ann. Chem. Synthesis of 7-unsubstituted 7H-pyrrolo[2,3-d]pyrimidines Pichler, H.;Folkers, G.;Roth, H. J.;Eger, K.
  12. J. Med. Chem. v.28 synthesis and 2,6-disubstituted 2'-deoxytubercidines prepared via the stereo-specific sodium salts glycosylation precedure Cottam, H. B.;Kazimierczuk, Z.;Geary, S.;Mckernan, P.;Revankar, G. R.;Robins, R. K.
  13. Arch. Pharm. (Weinhein) v.324 LDA-katalysierte diastereoselektive Michalel addition mit glycinderivaten: Synthese von 4-sub-stituierten 3-Aryl-2-ethoxycarbonyl-5-oxo-pyr-rolidine Pachaly, P.;Kang, H. S.;Wahl, D.
  14. Arch. Phar. (Weinheim) v.326 synthese von 7-Deazapurinen als potentielle purinanaloga Schick, W.;Pachaly, P.;Kang, H. S.;Wahl, D.
  15. 약학회지 v.37 7-데아자퓨린 유도체의 합성 신관석;남재우;이창규;전종갑