YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Studies on the Cytotoxic Constituent of Saururus chinensis$(L_{OUR.})\;B_{AILL.}$

삼백초의 세포독성 성분연구

  • Park, Si-Kyung (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Oh, Gab-Jin (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Bae, Choon-Il (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Kim, Hyun-Jong (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Han, Wan-Sik (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Chung, Sun-Gan (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Cho, Eui-Whan (Central Research Institute, Samjin pharmaceutical Co., LTD.)
  • 박시경 (삼진제약(주) 중앙연구소) ;
  • 오갑진 (삼진제약(주) 중앙연구소) ;
  • 배춘일 (삼진제약(주) 중앙연구소) ;
  • 김현종 (삼진제약(주) 중앙연구소) ;
  • 환완식 (삼진제약(주) 중앙연구소) ;
  • 정순간 (삼진제약(주) 중앙연구소) ;
  • 조의환 (삼진제약(주) 중앙연구소)
  • Published : 1997.12.01
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Abstract

In our search for bioactive natural products with antitumor activity, we have valuated various extracts of Saururi Herba (Saururaceae), which has been used in traditional medici ne for edema, beriberi, jaundice, turbid urine, carbuncle and furuncle. The hexane extract of the aerial part of this plant was found to show a potent cytotoxicity against several kinds of cultured human solid tumor cell lines (AGS, A549, HCT15, SKOV3, HEP-3B) in vitro. Using cytotoxicity-guided chromatographic separation of the hexane extract, cytotoxic constituent: 10-aminomethyl-3-hydroxy-4-methoxyphenanthrene-carboxylic acid lactam, was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.

Keywords

References

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