YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Alkaloids from the Tuber of Aconitum chiisanense

지리바꽃 괴경의 알카로이드

  • Published : 1997.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Tuber of Aconitum chiisanense(Ranunculaceae) a specific medicinal plant in Korea, which is known to have the activity to recover reduced metabolism of feeble patients and has been used to symptoms such as pain, paralysis, atonia and coldness of extremities, etc. were studied. The powdered tubers of the plant were extracted with 10% EtOH 3 times and the combined extract was dissolved in 1N HCl solution and washed with ethyl acetate. The aqueous layer was basified with solid $Na_2CO_3$ and extracted with $CHCl_3$ to obtain an alkaloidal fraction. The alkaloidal fraction was subjected to column chromatography using silica gel, alumina and Sephdex LH 20, etc. From the alkaloidal fraction, five diterpene alkaloids, mesaconitine, aconitine, hypaconitine, 8-O-ethyl 14-benzoylmesaconine and talatizamine, were isolated and identified on the basis of their physico-chemical properties and spectroscopic evidences($^1H$-, $^{13}C$-NMR, EI-MS, IR, 2D-NMR) respectively. Especially the Compound IV, 8-O-ethyl 14-benzoylmesaconine, was assumed to be an artifact resulting from mesaconitine during extraction procedures. The contents of mesaconitine, aconitine and hypaconitine in the mother tuber of this plant were 0.300%, 0.024%, and 0.068%. And that of the attached tuber(new one) of this plant were 0.336%, 0.034% and 0.240% respectively.

Keywords

References

  1. 大韓植物圖鑑 李昌福
  2. 韓國植物圖鑑 鄭台鉉
  3. 韓國藥品植物資源圖鑑 陸昌洙
  4. 原色韓國藥用植物圖鑑 陸昌洙
  5. 한국식물도감 문교부
  6. 藥品資源植物學 金一赫(外)
  7. 韓藥學Ⅱ 陸昌洙(外)
  8. Aconitum carmichaeli, ACTA Pharmaceutica Sinica v.12 no.7 Alkaloids of the chinese drug, Aconitum spp. Ⅸ alkaloids from Chuan-Wu and Fu-TZu Chen, Y.;Chu, Y. l.;Chu, J. H.
  9. Yakugaku Zasshi v.86 Alkaloids from Aconitum carmichaeli Isawa, I.;Naruto, S.
  10. Chem. Pharm. Bull. v.29 Structure Elucidation of a New Aconite. 15-α-Hydroxyneoline Takayama, H.;Hasegawa, S.;Sakai, S. I.;Haginiwa, J.;Okamoto, T.
  11. Chem. Pharm. Bull. v.30 no.2 Four New Lipo-Alkaloids From aconiti Tuber Kitagawa, I.;Yoshikawa, M.;Chen, Z. L.;Kobayashi, K.
  12. Journal of Natural Products v.45 no.2 Structure Senbusine A, B and C, Diterpenic Alkaloids of Aconitum carmichaeli Roots from China Konno, C.;Shirasaka, M.;Hikino H.
  13. Heterocycles v.18 Fuziline, A New Alkaloid From Chinese Drug "FUZI" (Aconitum carmichaeli) Pelletier, S. W.;Mody, N. V.;Varughesem K. I.
  14. Journal of Natural Products v.46 Structure of Hokbusine A and B, Diterpenic Alkaloids of Aconitum carmichaeli Roots From Japan Hikino, H.;Kuroiwa, Y.;Konno, C.
  15. Yakugaku Zasshi v.104 Chemical studies on Crude Drug Processing. Ⅱ. aconiti tuber(1). On the Constituents of "Chuan-wu", the Dried Tuber of Aconitum crmichaeli Kitagawa, I.;Chen, J. L.;Yoshihara L.;Yoshikawa L.
  16. Chem. Pharm. Bull. v.24 Studies on Cardiac Principle of Aconite Root Kosuge, T.;Yokoda, M.
  17. Yakugaku Zasshi v.99 On the alkaloids of Aconitum japonicum collected at Mt. Takao (Tokyo) Sakai, S. L.;Takayama, H.;Okamoto, T.
  18. Yakugaku Zasshi v.102 On the Alkaloids of Aconitum japonicum Collected at Mt. Mineoka (Chiba Pref.) : Structure Elucidation and Partial Synthesis of a New Alkaloid. 15-α-Hydroxyneoline Takayama, H.;Hasegawa, S.;Sakai, S.;Haginiwa, J.;Okamoto, T.
  19. Chem. Pharm. Bull. v.30 The Structure of Hypognavine Sakai, S. I.;Yamaguchi, K.;Yamamoto, I.;Okamoto, T.
  20. Chem. Pharm. bull. v.30 The Structure of A New Diterpene Alkaloid: Sanynamine Sakai, S. I.;Yamaguchi, K.;Takayama, H.;Yamamoto, I.;Okamoto T.
  21. Chem. Pharm. Bull. v.37 Two New Diterpene Alkaloids, 10-Hydroxyisotalatizidine and 10-Hydroxytalatizamine Takayama, H.;Hitotsuyanagi, Y.;Yamaguchi, K.;Aimi, N.;Sakai, S.I.
  22. Chem. Pharm. Bull. v.40 On the Alkaloidal Constituents of Aconitum sanuonense var. tonense Takayama, H.;Hitotsuyanagi, Y.;Yamaguchi, K.;Aimi, N.;Sakai S. I.
  23. Aconitum miyabei. Tetrahedron Letters v.46 The structure of Chaconitine and Isodelphinine From Aconitum muyabei Pelletier, S. W.;Mody, N. V.
  24. Yakugaku Zasshi v.98 On the Alkaloids of Aconitum gigas and the Structure of a New Base, Gigatonine Sakai, S. I.;Shinma, N.;Hasegawa, S.;Okamoto, T.
  25. Yakugaku Zasshi v.102 On the Alkaloids Aconitum yesonense Takayama, H.;Tokida, T.;Ito, M.;Sakai, S. I.;Kurosaki, K.;Okamoto, T.
  26. Phytochimistry v.29 $C_{19}$-Diterpenoid Alkaloids of Aconitum kongboense Yue, J. M.;Chen, Y. Z.;Li, Y. Z.
  27. Phytochimistry v.35 $C_{19}$-Diterpenoid Alkaloids of Aconitum kongboense Yue, J. M.;Jun, X.;Chen, Y. Z.
  28. Journal of Natural Products v.55 New Diterpenoid Alkaloids from the Roots of Aconitum septentrionale, Isolation by an Ion Exchange Method Sayed, H. M.;Desai, H. K.;Ross, S. A.;Pelletier, S. W.;Aasen, A. J.
  29. Phytochemistry v.36 Diterpenoid Alkaloids from Ayurvedic Processed and Unprocessed Aconitum ferox Hanuman, B. J.;Kazt, A.
  30. Chemical and Biological Perspective v.2 "in Alkaloids" Pelletier, S. W.;Mody, N. V.;Joshi, B. S.;Schramn, L. C.
  31. Yakugaku Zasshi v.98 Separation and Quantitative Analysis of Diterpene Alkaloids in Japanese Aonitum Roots Kurosaki, F.;Yatsunami, T.;Okamoto, T.;Ichinohe, Y.
  32. Pharm. Tech. Japan v.4 Analysis of Aconitine alkaloids in Aconite Roots Hikino, H.
  33. Journal of Chromatography v.211 ditermination of aconitine Alkaloids by High-Performance Liquid Chromatography Hikino, H.;Konno, C.;Watanabe, H.;shigawa, O.
  34. 道衛硏所報(第32集) 高速液體 クロマトグラフイ-による附子及ぴ烏頭 中のアコニチン系アルカロイドの定量 中野道晴;山岸喬
  35. Yakugaku Zasshi v.104 Chemical Studies on Crude Drug Processing. Ⅳ. aconit Tuber (3). Quantitative Determination of Aconitine alkaloids in aconiti Tuber by Means of High Performance Liquid Chromatography Kitagawq, I.;Chen, Z. L.;Yoshihara M.;Yoshikawa M.
  36. Plant Medica v.48 Determination of Aconitine Alkaloids in Aconitum Roots Hikino, H.;Murakami, M.;Konno, C.;Watanabe, H.
  37. Shoyakugaku Zasshi v.37 Seasonal Dynamics of the Accumulation of Aconitine Alkaloids in Aconitum carmichaeli Root Hikino, H.;shiota, S.;Takahachi, M.;Murakami, M.
  38. Alkaloids-Chemical and Biological Perspectives v.2 Pelletier, S. W.
  39. J. Am. Chem. Soc. v.98 Carbon-13 Nuclear Magnetic Resonance, Aconotinetype Diterpenoid Alkaloids from Aconitum and Delpiniiun Species Pelletier, S. W.;Djarmati
  40. Yakugaku Zasshi v.104 On the Alkaloids of Aconitum ibukiense Collected at Mt. Ryosen Sakai, S. I.;Yamamoto, I.;Hotoda, K.;Yamaguchi, K.;Aimi, N.;Yamanaka, E.;Haginiwa, J.;Okamoto, T.
  41. Allkaloids of Aconitum columbianum Pelletier, S. W.;Srivastava, S. K.;Joshi, B. S.