YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of The Optically Active Bicyclo [4.2.0. ] octanone by Stereoselective Intramolecular [2+2] Cycloaddition

입체선택적인 분자내 [2+2] 환화반응을 이용한 광학활성 Bicyclo[4.2.0.]octanone의 합성

  • Shim, Pil-Jong (College of Pharmacy, Sookmyung Women's University) ;
  • Kim, Hee-Doo (College of Pharmacy, Sookmyung Women's University)
  • 심필종 (숙명여자대학교 약학대학) ;
  • 김희두 (숙명여자대학교 약학대학)
  • Published : 1997.12.01
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Abstract

Stereoselective synthesis of the optically active bicyclo [4.2.0] octanone 5 was accomplished using intramolecular olefin-keteniminium salt[2+2]cycloaddition of the amide 4 as a key step. This important chiral synthon was prepared starting from readily available L-glutamic acid via an efficient 8-step sequence.

Keywords

References

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