The Journal of Korean Society of Virology (대한바이러스학회지)
- Volume 27 Issue 1
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- Pages.77-86
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- 1997
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- 1225-2344(pISSN)
Study on the Zidovudine Resistance of HIV-1 Isolated Strains in Korea
국내 HIV-1 분리주에 대한 Zidovudine의 저항성 연구
- Nam, Jeong-Gu (Center for AIDS Research, Department of Viral Disease, National Institute of Health) ;
- Kang, Chon (Center for AIDS Research, Department of Viral Disease, National Institute of Health) ;
- Lee, Joo-Shil (Center for AIDS Research, Department of Viral Disease, National Institute of Health) ;
- Lee, Hong-Rae (Center for AIDS Research, Department of Viral Disease, National Institute of Health) ;
- Shin, Dong-Yun (Center for AIDS Research, Department of Viral Disease, National Institute of Health) ;
- Park, Yong-Keun (Department of Biology, the Graduated School, Korea University) ;
- Shin, Yung-Oh (Center for AIDS Research, Department of Viral Disease, National Institute of Health)
- 남정구 (국립보건원 바이러스질환부 면역결핍연구실) ;
- 강춘 (국립보건원 바이러스질환부 면역결핍연구실) ;
- 이주실 (국립보건원 바이러스질환부 면역결핍연구실) ;
- 이홍래 (국립보건원 바이러스질환부 면역결핍연구실) ;
- 신동윤 (국립보건원 바이러스질환부 면역결핍연구실) ;
- 박용근 (고려대학교 생물학과 대학원) ;
- 신영오 (국립보건원 바이러스질환부 면역결핍연구실)
- Published : 1997.06.30
Abstract
To examine AZT resistance of HIV-1 isolates from AZT treated or untreated Korean, several biological characteristics such as syncytium formation, HIV-1 reverse transcriptase activity and the p24 antigen production in MT-2 cells infected with 4 HIV-1 isolates were determined. As controls, we tested HIV-1 HTLV-IIIB and pre-drug isolate as AZT susceptible strains, in addition to HIV-1 RTMC/MT-2 and post-drug isolate as AZT resistant strains. When the inoculum size of HIV-1 was 300