Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
권호 표지
DOI QR코드

DOI QR Code

Stabilization of Poly(dA)·[poly(dT)]₂Triple Helical DNA by Acridine Derivatives: Role of Side Chain in the Triplex Stabilization

  • Published : 1997.05.20
Download PDF
⟨ Previous Next ⟩

Abstract

The conformation and stabilization effects of acridine derivatives 9-aminoacridine, an acridine with an aminoalkyl side chain, bis acridine (two acridines linked by an aminoalkyl side chain), and proflavin in the triplex helical poly(dA)·[poly(dT)]2 were investigated by optical spectroscopies. Based on the negative LD and weak positive CD in the acridine absorption wavelength region, we concluded that the acridine moiety of all derivatives are intercalated. We also examined the melting temperatures. Of all the compounds examined, the acridine with an amino alkyl side chain had the strongest effect on the stabilization of the third strand of a poly (dA)·[poly(dT)]2 triplex. The role of the side chain, based on this observation, is discussed.

Keywords

References

  1. Nucleic Acids Res. v.15 LeDoan, T.;Perrouault, L.;Praseuth, D.;Habhoub, N.;Decout, J. L.;Thuong, N. T.;Lhomme, J.;Helene, C.
  2. Science v.238 Moser, H. E.;Dervan, P. B.
  3. Nucleic Acids Res. v.16 Lyamichev, V. I.;Mirkin, S. M.;Frank-Kamenetskii, M. D.;Cantor, C. R.
  4. Nature v.330 Mirkin, S. M.;Lyamichev, V. I.;Drushlya, K. N.;Dobrynin, V. N.;Filipov, A.;Frank-Kamenetskii, M. D.
  5. FASEB J. v.2 Wells, R. D.;Collier, D. A.;Hanvey, J. C.;Shimizu, M.;Wohlrab, F.
  6. Science v.243 Htun, H.;Dahlberg, J. E.
  7. Methods Enzymol. v.211 Htun, H.;Dahlberg, J. E.
  8. Angew. Chem. Int. Eng. v.32 Thuong, N. T.;Helene, C.
  9. Science v.241 Cooney, M.;Czernuszewic, G.;Postel, E. H.;Flint, S. J.;Hogan, M. E.
  10. Proc. Natl. Acad. Sci. USA v.88 Postel, E. H.;Flint, S. J.;Kessler, D. J.;Hogan, M. E.
  11. Proc. Natl. Acad. Sci. USA v.88 Young, S. L.;Krawcxyk, S. H.;Matteucci, M. D.;Toole, J. J.
  12. Proc. Natl. Acad. Sci. USA v.89 Duval-Valentine, G.;Thuong, N. T.;Helene, C.
  13. J. Biol. Chem. v.267 Grigoriev, M.;Praseuth, D.;Robin, P.;Hemar, A.;Saison-Behmoaras, T.;Dautry-Varsat, A.;Thuong, N. T.;Helene, C.;Harel-Bellan, A.
  14. Nucleic Acids Res. v.18 Birg, F.;Praseuth, D.;Zerial, A.;Thuong, N. T.;Asseline, U.;LeDoan, T.;Helene, C.
  15. Proc. Natl. Acad. Sci. USA v.90 Giovannangeli, C.;Thuong, N. T.;Helene, C.
  16. Biochemistry v.28 Francois, J. C.;Saison-Behmoaras, T.;Thuong, N. T.;Helene, C.
  17. Science v.245 Maher, L. J. III.;Wold, B.;Dervan, P. B.
  18. Nucleic Acids Res. v.18 Hanvey, J. C.;Shimizu, M.;Wells, R. D.
  19. J. Biomol. Str. Dyn. v.3 Lyamichev, V. I.;Mirkin, S. M.;Frank-Kamenetskii, M. D.
  20. Science v.241 Htun, H.;Dahlberg, J. E.
  21. Science v.241 Johnston, B. H.
  22. Proc. Natl. Acad. Sci. USA v.88 Takasugi, M.;Guendouz, A.;Chassignol, M.;Decout, J. L.;Lhomme, J.;Thuong, N. T.;Helene, C.
  23. Proc. Natl. Acad. Sci. USA v.90 Giovannangeli, C.;Thuong, N. T.;Helene, C.
  24. Proc. Natl. Acad. Sci. USA v.86 Sun, J. S.;Francois, J. C.;Montenay-Garestier, T.;Saison-Behmoaras, T.;Roig, V.;Thuong, N. T.;Helene, C.
  25. Science v.256 Megny, J. L.;Duval-Valentine, G.;Nguyen, C. H.;Peroault, L.;Faucon, B.;Rougee, M.;Montenay-Garestier, T.;Bisagni, E.;Helene, C.
  26. Biochemsitry v.32 Lee, J. S.;Latimer, L. J. P.;Hampel, K. J.
  27. J. Am. Chem. Soc. v.115 Plich, D. S.;Waring, M. J.;Sun, J. S.;Roug, M.;Nguyen, C. H.;Montenay-Garestier, T.;Helene, C.
  28. J. Mol. Biol. v.232 Pilch, D. S.;Waring, M. J.;Sun, J. S.;Roug, M.;Nguyen, C. H.;Montenay-Garestier, T.;Helene, C.
  29. Biochemistry v.32 Wilson, W. D.;Tanious, F. A.;Mizan, S.;Yao, S.;Kiselyov, A. S.;Zon, G.;Strekowski, L.
  30. J. Biol. Chem. v.266 Scaroa, P. V.;Shafer, R. H.
  31. Bioorg. Med. Chem. v.3 Tuite, E.;Norden, B.
  32. Biochemistry v.35 Kim, H.-K.;Kim, J.-M.;Kim, S. K.;Rodger, A.;Norden, B.
  33. Biochemistry v.31 Howard, F. B.;Todd Miles, H.;Liu, K.;Frazier, J.;Raghunathan, G.;Sasisekharan, V.
  34. J. Am. Chem. Soc. v.112 Umemoto, K.;Sarma, M. H.;Gupta, G.;Luo, J.;Sarma, R. H.
  35. J. Biol. Chem. v.267 Durand, M.;Thuong, N. T.;Maurizot, J. C.
  36. J. Biomol. Str. Dyn. v.11 Durand, M.;Thuong, N. T.;Maurizot, J. C.
  37. FEBS Lett. v.315 Kim, S. K.;Norden, B.
  38. J. Chem. Soc., Chem. Commun. Tuite, E.;Norden, B.
  39. Biopolymer v.31 Lyng, R.;Rodger, A.;Norden, B.
  40. Biopolymer v.32 Lyng, R.;Rodger, A.;Norden, B.
  41. Rev. Biophys. v.25 Norden, B.;Kubista, M.;Kurucsev, T. Q.
  42. Appl. Spectrosc. v.39 Norden, B.;Seth, S.
  43. J. Mol. Recognit. v.7 Norden, B.;Kurucsev, T.
  44. Chem. Phys. Lett. v.85 Matsuoka, Y.;Norden, B.
  45. Chem. Phys. Lett. v.117 Fornasiero, D.;Kurucsev, T.
  46. Biopolymers v.29 Swenberg, C. E.;Carberry, S. E.;Gecacintov, N. E.