Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Stereocontrolled Synthesis of 4-Acetoxy-2-azetidinone via Double Azetidinone Ring Formation : A Useful Precursor of Carbapenem and Penem Antibiotics

  • 권희안 (중외제약(주)중앙연구소) ;
  • 이미정 (중외제약(주)중앙연구소) ;
  • 이인희 (중외제약(주)중앙연구소) ;
  • 이수진 (중외제약(주)중앙연구소) ;
  • 윤택현 (중외제약(주)중앙연구소) ;
  • 황태섭 (중외제약(주)중앙연구소)
  • Published : 1997.05.20
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Abstract

(3R,4R)-4-Acetoxy-3-[(1'R-tert-butyldimethylsilyloxy)ethyl]-2-azetidinone, one of the best synthons for carbapenems and penems was efficiently synthesized from readily available L-threonine via double azetidinone ring formation.

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References

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