Biomolecules & Therapeutics
- Volume 5 Issue 2
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- Pages.174-178
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- 1997
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
Immunotoxicity Study of Combined Vaccine (KGCC-95Vl) against Japanese Encephalitis and Hantaan Virus Infection in Guinea Pigs
- Shin, Kwang-Soon (Veterinary Research Institute, College of Veterinary Medicine, Chungnam National University) ;
- Kim, Chul-Joong (Veterinary Research Institute, College of Veterinary Medicine, Chungnam National University) ;
- Yun, Hyo-In (Veterinary Research Institute, College of Veterinary Medicine, Chungnam National University) ;
- Shin, Hyeong-Soon (Department of Biotechnology, Inha University) ;
- Park, Jong-Il (Toxicology Research Center, KRICT) ;
- Cha, Shin-Woo (Toxicology Research Center, KRICT) ;
- Oh, Kyu-Ho (Central Research Institute, Korea Green Cross Corp.) ;
- Song, Dong-Ho (Central Research Institute, Korea Green Cross Corp.) ;
- Ahn, Chang-Nam (Central Research Institute, Korea Green Cross Corp.)
- Published : 1997.06.01
Abstract
The immnunogenicity of the possible non-essential component of the combined vaccine (KGCC-957) for the prophylaxis against Japanese encephalitis and Hantaan virus infection recently developed by Korea Green Cross Corporation was investigated using the Hartley guinea pigs. The KGCC-95Vl was administered to the guinea pigs subcutaneously to sensitize the animals. The guinea pigs did not induce any anaphylactic immune responses which could be detectable by the active systemic anaphylaxis (ASA), the passive systemic anaphylaxis (PSA), and the passive cutaneous anaphylaxis (PCA) tests. The KGCC-95Vl is considered not to induce any anaphylactic immune responses except the prophylatic immune effects of the vaccine.