Journal of Environmental Science International (한국환경과학회지)

The Korean Environmental Sciences Society (한국환경과학회)
권호 표지

Histological and Histochemical Study on Toxicity of Ricin in the Rat Liver

흰쥐 간에 미치는 Ricin의 독성에 대한 조직학적 및 조직화학적 연구

  • 조운복 (부산대학교 생물교육과) ;
  • 최병태 (부산대학교 생물교육과, 고신대학교 해부학교실, 경성대학교 생물학과, 고신대학교 생물학과)
  • Published : 1997.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

The toxicity of purified ricln from Ricinus communis to rats was examined by histological and histochemical methods. Sprague-Dawley rats were injected intraperitoneally with 75$\mu\textrm{g}$/kg body weight of ricin and were sacrified at itntervals of 6, 24, 48 and 120 hours after injectoon. The major morphological changes, such as cloudy swelling, hydropic degeneration, necrosis, fatty change, blood congestion, increase of Kupffer cells in number and extension of sinusoids, were obvious in the liver of experimental group. These morphological changes of hepatic cells were mainly observed in both the periportal and midlobular region of hepatic lobule. The extension of sinusoids was obvious in the controlobular region. And glycogen dlstrlbution of hepatic cells tended to decrease in the same region showing morphlogical changes as compared with the control group.

Keywords

References

  1. 부산의대잡지 v.16 생후 발육기에 있는 흰쥐의 간조직내 glycogen 분포 및 몇종 효소의 분포상태에 관한 조직화학적 연구 박해춘
  2. 대한해부학회지 v.11 Parathion이 mouse간세포의 미세구조에 미치는 영향 이동식;김숙영;이규식
  3. 대한해부학회지 v.19 백서에서 비만 세포 탈과립, 간의 당원함량 및 효소활성, 담즙생산에 미치는 compound 48/80의 영향 장영숙;전병득;이무삼
  4. Am. J. Anat. v.140 Hepatic glycogen pattern in fasted and fed rats Babcoke, B.B.;R.R. Cardell
  5. J. Cell Physio. v.129 Dexamethasone and dimethyl sulfoxide as distinct regulators of growth and differentiation of cultured suckling rat hepatocytes Baribault, H.;N. Mareau
  6. Arch. Biochem. Biophysic. v.190 Homology between ricin and Ricinus communis agglutinin: Amino terminal sequence analysis and protein synthesis inhibition studies Cawley, D.B.;M.L. Hedblom;L.L. Houston
  7. Lab. Invest. v.26 Mechanism of carbon tetrachloride hepatotoxicity Chopra, P.;S. Roy;V. Ramalingaswami;N.C. Nayak
  8. J. Biol. Chem. v.262 The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes Endo, Y.;K. Mitsui;M. Motizuki;K. Tsurungi
  9. Br. J. Cancer v.34 Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice Fodstad, φ.;S. Olsnes;A. Pihl
  10. J. Cell Biol. v.83 An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver Hubbard, A.L.;G. Wilson;G. Ashwell;H. StuKenbrok
  11. Korean Biochem. J. v.26 Isolation and biochemical properties of ricin from Ricinus communis Jang, H.Y.;J.H. Kim
  12. J. Korean Soc. Food Nutr. v.23 Alleviatiing effects of vitamin C on the gramoxone toxicity in rat liver Jo, U.B.;S.R. Kim
  13. Immunol. Cell Biol. v.66 In vivo studies of whole ricin monoclonal antibody immunoconjugates for the treatment of murine tumors Kanellos, J.K.;I.F.C. MacKenzie;G.A. Pietersz
  14. Eur. J. Biochem. v.105 Purification and physicochemical properties of ricins and agglutinins from Ricinus communis Lin, T.;S. Li
  15. J. Biol. Chem. v.256 Oligosaccharide specific endocytosis by isolated rat hepatic reticuloendothelial cells Maynard, Y.;J.U. Baenziger
  16. Stain Tech. v.23 Periodic acid Schiffs reation McManus, J.F.A.
  17. Nature v.328 Closing in ricin action Olsnes, S.
  18. Biochemistry v.12 Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibitory protein synthesis Olsnes, S.;A. Phil
  19. J. Biol. Chem. v.234 Biochemical changes in carbon tetra-chloride fatty liver: Separation of fatty changes from mitochondrial degeneration Recknagel, R.O.;O.D. Anthony
  20. J. Biol. Chem. v.257 Entry of the toxic proteins abrin, modeccin, ricin and diphtheria toxin into cells Sandvig, K.;S. Olsnes
  21. Cancer v.47 The relationship of the possible hepatic toxicity of chemotherapeutic drugs and carcinoembryonic antigen elevation Sarvin, R.A.;E.W. Martin
  22. Lectins Sharon, N.;H. Lis
  23. J. Biol. Chem. v.255 On the role of the covalent carbohydrate in the action of ricin Simeral, L.S.;W. Kapmeyer;W.P. Mac-Connell;N.O. Kaplan
  24. Science v.183 Persistence of cadmium-induced metabolic changes in liver and kidney Singhal, R.L.;Z. Merall;S. Kacew;D.J.B. Sutherland
  25. Biochimica et Biophysica Acta v.677 A comparison of the accumulation of ricin by hepatic paren-chymal and non-parenchymal cells and its inhibition of protein synthesis Skilleter, D.N.;A.J. Paine;F. Stirpe
  26. J. Exp. Med. v.116 An intracellular defect in protein synthesis induced by carbon tetrachloride Smuckler, E.A.;O.A. lseri;E.P. Benditt
  27. Science v.140 Carbon tetrachloride poisoning in rats; Alteration in ribosomes of the liver Smuckler, E.A.;E.P. Benditt
  28. Am. J. Clin. Nutr. v.31 Longterm effectiveness of dietary iron and ascorbic acid in the prevention and cure of cadmium toxicity in rats Suzuki, T.;A. Yoshida
  29. Fed. Proc. v.21 Acute carbon tetrachloride effects in mouse liver Taft, E.B.;J.F. Scott;J.B. Caufeld
  30. Eur. J. Biochem. v.147 Modification of the carbohydrate in ricin with metaperiodate - cyano - borohydride mixtures Thorpe, P.E.;S.I. Detre;B.M.J. Foxwell;A.N.F. Brown;D.N. Skilleter;G. Wilson;J.A. Forrester;F. Stirpe
  31. Science v.238 Redesigning nature's poisons to create anti-tumor reagents Vitetta, E.S.;R.J. Fulton;R.D. May;M. Till;J.W. Uhr