Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of Dietary CHitin, Chitosan and NOCC on Cadmium Toxicity and Lipid Metabolism in Rats

Chitin, CHitosan 및 수용성 Chitosan 유도체가 흰쥐의 Cadimium 중독과 지방대사에 미치는 영향

  • 배계현 (이화여자대학교 식품영양학과)
  • Published : 1997.07.01
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Abstract

This study was to investigate the effects of chitin, chitosan , NOCC and cellulose on cadmium toxicity and lipid metabolism in rats. Fifty male rats of Sprague-Dawley strain weighing 155$\pm$17g were divided into 10 groups according to body weight, and were raised for 5 weeks. Levels of 0 and 400 ppm of cadmium chloride were in the diets. And chitin, chitosan , NOCC and cellulose were given at the level of 0 and 4%(w/w) of the diets. Chitosan and NOCC decreased Cd concentration of liver and kidney, and increased the fecal excretion of Cd. Although cellulose was less effective, cellulose also decreased Cd concentration of liver and increased fecal Cd excretion . However chitin had little effect on alleviating Cd toxicity. In addition, chitosan and NOCC lowered total lipid, cholesterol and triglyceride contents in serum and liver by decreasing the lipid absorption. The lowering of cholesterol especially had a remarkable effect. Although it was less effective than chitosan and NOCC, chitin decreased the lipid absorption ratio and lowered cholesterol contents in serum and liver. In conclusion , chitosan and NOCC showed effects of decreasing the absorption of Cd and lipid.

Keywords

References

  1. Environ Health Perspect v.54 Intracellullar metabolism and effects of circulating cadmium-metallothionein in the kidney Squibb KS;Fowler BA
  2. Br J Ind Med v.35 The effect of body protein supply on resistance to cadmium Gontzea I;Popescu F
  3. Environ Res v.28 Controlling cadmium in the human food chain : A review and retionale based on health effects Ryan JA;Pahren HR;Lucas JB
  4. In : Cadmium in the Human Environment IARC Scientific Publications no.118 Factors affecting the international uptake of cadmium from the diet Anderson O;Nielson JB;Nordberg GF
  5. 한국식품과학회지 v.18 서울시내 대중식사로부터 중금속의 총섭취량 평가 송미란;이서래
  6. 한국영양식량학회지 v.18 대중음식중 중금속 함량 김정헌;조남준;박성배
  7. 국립환경연구원보 v.12 중금속의 생체독성 저감연구 조윤승;이방희;최광수;조태웅
  8. In : Cadmium Absorption of Cadmium Foulkes ED
  9. Nutr Sci Vitaminol v.23 Effects of dietary protein, Ca, P, fiber on renal accumulation of exogenous Cd in young rats Omori M;Muto Y
  10. Biochem Pharmacol v.21 Binding of cadmium ions by rat liver and kidney Webb M
  11. Acta Med Scand v.138 Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning Friberg L
  12. Lancet v.1 Godding EW Dietary fiber redifined(letter)
  13. In : Dietary Fiber-Basic and Clinical Aspects The relationship between composition and properties of dietary fiber and physiological effects Southgate DAT
  14. In : Dietary Fiber-Basic and Clinical Aspects Hypocholesterolemic effects of soluble fibers Chen WJL;Anderson JW
  15. Am J Clin Nutr v.42 The effects of fiber components pectin, cellulose and lignin on serum cholesterol levels Hillman LC;Peters SG;Fisher CA
  16. Preecedings from the 4th International Conference on Chitin and Chitosan Chitosan : Commercial uses and protential application Sandford PA
  17. Am J Clin Nutr v.33 A novel use of chitosan as a hypocholesterolemic agent in rats Sugano M;Fujikawa T;Hirasuji Y;Nakashima K;Fukada N;Hasegawa Y
  18. Nutr Rept Int v.20 The hypolipidemic activity of chitosan and other polysaccharide in rats Nagyvary JJ;Falk JD;Hill ML;Schmidt ML;Willkilns AK;Bradbury EL
  19. Am J Clin Nutr v.38 Comparative effects of chitosan and cholestyramine on lymphatic absorption of lipids in the rat Vahouny GV
  20. In : Chitin and Chitosan Skijak-Break G;Anthosen T;Sandford PA
  21. In : Chitin Muzzarelli RAA
  22. Food Technol v.23 Use of chitinous polymers in food Knorr D
  23. Talanta v.18 Chitosan for the collection from sea water of naturally occuring Zn, Cd, Pb and Cu Muzzarelli RAA
  24. Talanta v.16 Chitin and chitosan as chromatographic suppotrs and adsorbenys for collection of metal ions fron organic and aqueous solutions and sea water Muzzarelli RAA;Tubertini O
  25. US Patent v.4 N,O-carboxymethyl chitosan and preparative method therefor Hayes ER
  26. J Food Sci v.47 Fundtional properties of chitin and chitosan Knorr D
  27. In : Chitin In : Natural chelating polymers, Pergamon, Oxford, 1973 Muzzarelli RAA
  28. Chem Pharm Bull v.30 Studies on poisonous metals, Ⅸ Effects of dietary fibers on absorption of Cd in rats Kiyozumi M;Mishima M;Moda S
  29. Br J Nutr v.58 The effect of wheat bran on the absorption and accumulation of cadmium in rats Moberg A;Hallmans G
  30. 이화여자대학교 석사학위논문 Chitin, chitosan이 흰쥐의 Cadmium 중독과 지방대사에 미치는 영향 설은영
  31. Biopolymers v.15 N-acetylchitosan gel : A polyhydrate of chitin Hirano S;Yamaguchi R
  32. J Lab Clin Med v.78 Atomic absorption determination of lead in blood and urine in the presence of EDTA Zinterhofer LJM;Jatlow I;Fappino A
  33. Environ Sci Technol v.5 Determination of lead in biological and related material by atomic absorption spectrophotometry Yeager DW;Cholak J;Hendersen EW
  34. Am J Clin Pathol v.53 Improved method for ditermination of triglycerides in serum Frings CS;Dunn RT
  35. Can J Biochem Psysiol v.37 A rapid method of total lipid extraction and purification Bligh EG;Dyer WJ
  36. Am J Clin Pathol v.24 Rapid estimation of free and total cholestsrol Zak B
  37. Clin Chem v.19 A colorimetric method for determination of total serum lipids based on the sulpho phospho-vanillin reaction Neri BP;Frings CS
  38. In : Principles and Procedures of Satistics Steel RGD;Torrie JH
  39. Acta Pharmacol Toxicol v.41 Interactions of cadmiun with copper, zinc and iron in different organs and tissues of the rat Juhlshamn K;Utne F;Bracckan OR
  40. Toxicol Appl Pharmacol v.75 Interaction between calcium and cadmium in the 1,25 dihydroxy vitamine D3 stimulated rat duodenum Torrason M;Foulkes EC
  41. J Nutr v.103 Cadmium toxicity in growing swine Cousins RJ;Barber AK;Trout JR
  42. Nutr Rap Int v.8 Inflience of Cd on the metabolism of 25-hydroxy cholecalciferol in chicks Feldman SL;Cousins RJ
  43. J Nutr v.107 Role of dietary calcium and calcium binding protein in cadmium toxicity in rats Washko PW;Cousins RJ
  44. Nutr Rev v.39 Nutritional factors in lead poisoning Mahaffey KR
  45. Environ Res v.15 Studies on metallothionein and cadmium Nordberg M
  46. Environ Health Perspect v.54 Metallothionein in rabbit kidneys preserved for tramsplantation Elinder CG;Lundgran M;Nordberg B
  47. 이화여자대학교 박사학위논문 식이단백질과 calcium수준이 흰쥐의 Cadmium중독 및 해독에 미치는 영향 권오란
  48. In : Cadmium Role of metallothionein in cadmium metabolism Webb M
  49. J Toxicol Environ Health v.7 Cadmium, copper and zincdistribution in blood of rats after long term subcutaneous administration Suzuki Y
  50. Carbohydrate Res v.S3 Enhancement of the metal chelating properties of chitosan Hall LD;Yalpani M
  51. J Appl Poly Sci v.27 Interaction of heavy metals chitin and chitosan Wightman JP;Maruca R;Sudder BJ
  52. In : Unconventional Sources of Dietary Fiber Aminopolysaccharides-their potential as dietary fiber Furda I
  53. Carbohydrate Res v.107 N-(carboxymethylidine)chitosan and N-(carboxymethyl)-chitosan : Novel chelating polyampholytes obtained from chitosan glyoxylate Muzzarelli RAA
  54. Korean J Nutr v.22 Effect of dietary fiber on lead absorption and metabolic changes in growing rats Kim MK;Lee HY
  55. 이화여자대학교 석사학위논문 식이단백질 및 식이섬유질이 납중독 흰쥐의 단백질과 납 대사에 미치는 영향 김지희
  56. In : Cadmium in the Human Environment Ciritical levels of blood and urinary β2-microglobulin and retinol-binding protein for monitoring cadmium health effects Nomiyama K;Liu SJ;Nomiyama H
  57. Nutr Rev v.49 Soluble fiber polysaccharides : Effects on plasma cholesterol and colonic fermentation Topping DL
  58. Am J Clin Nutr v.32 Plant fiber : Carbohydrate and lipid metabolism Anderson JW;Chen WJI
  59. J Nutr Sci Vitaminol v.38 Effect of dietary chitin on cholesterol absorption and metabolism in rats Zacour AC;Silva ME;Cecon PR
  60. 이화여자대학교 석사학위논문 게껍질에서 추출된 chitin 및 chitosan의 소화관내 지방질 흡착에 관한 in vitro 연구 장현주
  61. Proceedings from the 4th International Conference on Chitin and Chitosan Production and application of chitin and chitosan Hirano S
  62. Proc Soc Exp Biol Med v.162 Effects of plant fiber in decreasing plasma total cholesterol and increasing high-density lipoprotein cholesterol Chen WJL;Anderson JW
  63. Proc Soc Exp Biol Med v.189 A comparison of the lipid lowering and intestinal morphological effects of cholestiramine, chitosan and oat gum in rats Jenings CD;Boleyn K;Bridges SR;Wood PJ;Anderson JW
  64. Endocrinology v.132 Some effects of chitosan on liver function in the rats Lehoux JG;Groundin F
  65. J Nutr v.119 International effects of dietary fiber and fat on lymphatic cholesterol and triglyceride absorption in rats Ikeda L;Torami Y;Sugano M
  66. J Agric Food Chem v.41 Effects of chitosan hydrolysates on lipid absorption and on serum and liver lipid concentration in rats Ikeda I;Sugano M;Yoshida K
  67. Lipids v.23 Hypocholesterolemic action of chitosans with different viscosity in rats Sugano M;Watanabe S;Kishi A;Izumi M;Ontakara A
  68. Fed Proc v.41 Dietary fiber, lipid metabolism and atherosclerosis Vahouny GV
  69. Lipids v.18 The binding of micellar lipids to chitosan Nauss JL;Thomson JL