Journal of the Korean Society of Tobacco Science (한국연초학회지)

The Korean Society of Tobacco Science (한국연초학회)
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Inhibition of Monoamine Oxidase B by Cigarette Smoke Constituents

  • Published : 1997.12.01
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Abstract

Cigarette smoking is known to suppress both 1-methy14-phenyl-155,Ltetrahydropy-ridine (MPTP)-induced parkinsonism and idiopathic Parkinson's disease (PD). However, the precise mechanism underlying its protective action against PD is not clearly elucidated yet. In order to find possible clue on the mechanism of protective action of smoking, we investigated the inhibitory effect of cigarette smoke components on rat brain mitochondria1 monoamine oxidase B (MAO-B), responsible enzyme for the activation of MPTP to its toxic metabolitesr and identified the components having an inhibitory potency on this enzyme from cigarette smoke. Total 31 eligible constituents including nicotine were selected from cigarette smoke condensates via solvents partitioning and silica gel chromatographic separation, and inhibitory potencies of 19 components on MAO-B were determined. Hydroquinone and methylcatechol, the phenolic components, showed the strongest inhibitory potencies on MAO-B activity in the components tested. 3,4-Dihydroxybenzylamino, myosmine and indole in basic fracton, eugenol in phenolic fraction, and farnesol in neutral fraction also inhibited the enzyme activity dose-dependently. Among tobacco alkaloids tested only myosmine was effective for the inhibition of this enzyme. These results suggest that the decrease in MAO-B activity by such components derived from cigarette smoke seems to be related to the suppression of MPTP-induced neurotoxicity and to the less incidence of Parkinson's disease in smokers than in nonsmokers.

Keywords

References

  1. Advances in Pharmacological Sciences Acute biological effects of nicotine and its metabolite: Effect of nicotine on biological system Ⅱ Benowitz, N.L.
  2. Lancet v.1 Biogenic amine adducts, monoamine oxidase inhibitors and smoking Boulton, A.A.;Yu, P.H.;Tipton, K.E.
  3. Lancet v.2 The aetiology of Parkinson's disease Calne, D.B.;Langston, J.W.
  4. Neuropharmacol v.29 Attenuation of MPTP induced neurotoxicity by tobacco smoke Carr, L.A.;Rowell, P.P.
  5. Br. J. Pharmaco; v.85 Electrophysiological actions of nicotine on substantia nigra single units Clarke, P.B.S.;Hommer, D.W.;Pert, A.;Skirboll, L.R.
  6. Nature v.379 Inhibition of monoamine oxidase B in the brains of smokers Fowler, J.S.;Velkow, N.D.;Wang, G.J.;Nappas, N.;Logan, J.;MacGreger, R.;Alexoff, D.;Shea, C.;Schlyer, D.;Welf, A.P.;Warner, D.;Zezulkova, I.;Cilento, R.
  7. Am. J. Epid. v.139 Prospective study of cigarette smoking and the risk of developing idiopathic Parkinson's disease Grandinetti, A.;Morens, D.M.;Reed, D.;Mac-Eachem, D.
  8. Neuroepidemiol v.12 Induction of cytochrome P-450 enzymes via tobacco smoke: a petential mechanism for developing resistance to environmental toxins as related to Parkinsonism and other neurologic diseases Gresham, L.S.;Molgard, C.A.;Smith, R.A.
  9. Proc. Am. Public Health Ass. 123rd Annual Meeting. Smoking and idiopathic Parkinson's disease: Meta-analysis Heller, W.D.;Tricker, A.R.;Adikofer, F.
  10. Biogenic Amines v.4 Is the monoamine oxidase B activity rate limiting for MPTP neurotoxicity? Jossan, S.S.;Sakurai, E.;Orland, E.
  11. Proc. Natl. Acad. Sci. USA. v.84 Correlation of MPTP neurotoxicity with blood-brain barier monoamine oxidase activity Kalaria, R.N.;Mitchell, M.J.;Harik, S.
  12. Euro. Neurol v.26 MPTP: insights into the etiology of Parkinsons disease Langston, J.W.
  13. J. Kor. Soc. Tobac. Sci. v.18 Effect of cigarette smoke exposure on MPTP-induced neurotoxicity in mice Lim, H.B.;Sohn, H.O.;Lee, Y.G.;Lee, D.W.
  14. Proc. 3rd. Annual Meeting, of the Society for Research on Nicotine and Tobacco Protection of MPTP neurotoxicity by cigarette smoke and its possible mechanism Moon, J.Y.;Lim, H.B.;Sohn, H.O.;Lee, Y.G.;Kang, Y.K.;Lee, D.W.
  15. J. Pharmacol. Method. v.13 An improved fluorometric assays for brain monoamine oxidase Morinan, A.;Garratt H.M.
  16. Biosci. Biotech. Biochem. v.58 Tobacco Tar components that stimulate nerve growth factor (NGF) synthesis/secretion of mouse asfroglial cells in culture Murase, L.;Shimizu, Y.;Hayashi, K.
  17. Brain Research v.534 Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in goldfish brain Poli, A.;Guarnieri, T.;Facchinetti, F.;Villani, L.
  18. Neurosci. Lett. v.127 no.2 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: partial protection against striato-nigral dopamine depletion in C57BL/6J mice by cigarette smoke exposure and by beta-naphthoflavone-pretreatment Shahi, G.S.;Das, N.P.;Moochhala, S.M.
  19. Neurosci. Lett. v.93 Effect of chronic oral nicotine on dopaminergic function in the MPTP-treated mouse Sershen, H.;Hashim, A.;Wiener, H.L.;Lajtha, A.
  20. Ann. Neurol. v.28 Effect of deprenyl on neuropsychological function in early Parkinsons disease The Parkinson Study Group
  21. J. Neurol. Sci. v.72 Monoamine oxidase B, smoking, and Parkinson's disease Yong, V.W.;Perry, T.L.
  22. Life Sci. v.41 Irreversible inhibition of monoamine oxidase by some components of cigarette smoke Yu, P.H.;Boulton, A.A.