한국연초학회지 (Journal of the Korean Society of Tobacco Science)

한국연초학회 (The Korean Society of Tobacco Science)
권호 표지

흡연자 및 비흡연자의 뇨중 니코틴 및 코티닌 함량

Measurement of Urinary Nicotine and Cotinine Values in Smokers and Non-smokers

  • 이문수 (한국인삼연초연구원 분석부) ;
  • 나도영 (한국인삼연초연구원 분석부) ;
  • 황건중 (한국인삼연초연구원 분석부)
  • 발행 : 1997.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was conducted to evaluate the personal effects of tobacco smoke and environmental tobacco smoke(ETS) by measuring the concentration of nicotine and cotinine in the urine. While 129 urine samples were being collected, Personal characteristics such as sex, age, number of years since a Person has been a smoker, average consumption number of cigarettes per day, and number of smoker in family were also surveyed. Collected urine samples were used for analysis of nicotine and cotinine by GC/NPD after Passing the extrelut column. In the urine of the smoker, the average contents of nicotine and cotinine were 5.38$\mu\textrm{g}$/ml and 3.14 $\mu\textrm{g}$/ml, respectively. The average contents of nicotine and cotinine were 0.18$\mu\textrm{g}$/ml and 0.07$\mu\textrm{g}$/ml in the urine of male non-smoker, respectively. The contents of nicotine and cotinine in the non-smoker's urine were dependent on sex and age. On the other hand, the contents of nicotine and cotinine in smoker's urine were dependent on average consumption amount of cigarettes per day. Also, there was a direct relation between nicotine levels in the smoker's urine and the average consumption number of cigarettes Per day of smoker. The Possible sources of nicotine and cotinine in the non-smoker's urine seemed to be caused by food, beverage and En, Our results indicate that the number of smoker in family had no effect on increasing nicotine and cotinine contents in the urine of non-smoker.

키워드

참고문헌

  1. Clinical Pharmacology and Therapeutics v.34 Cotinine disposition and effects Benowitz, N. L.;F. Kuyt;P. Jacob;A. Osman
  2. research advances on alcohol and drug problems v.9 The human pharmacology of nicotine Benowitz, N. L.
  3. Archives of Envir. Health v.45 Measurement of current exposure to environmental tobacco smoke Cummings, K. M.;S. J. Markello;M. Mahoney;A. K. Bhargava;P. D. McElroy;J. R. Marchall
  4. European J. of Clinical Pharmacology v.38 The pharmaco kinetics of cotinine in plasma and saliva from non-smoking healthy volunteers Curvall, M.;C. Elwin;E. Kazemi-Vala;C. Qarholm;C. R. Enzell
  5. Fd. Chem. Toxic v.29 Dietary nicotine: A source of urinary cotinine Davis, R. A.;M. F. Stiles;J. D. Eebethizy;J. H. Reynolds
  6. Mutation Research v.223 Human urine mutagenicity study comparing cigarettes which burn or only heat tobacco Doolittle, D. J.;C. A. Rahn;G. T. Burger;R. Davis;C. K. Lee;A. W. Hayes
  7. British Medical J. v.284 Nicotine concentrations in urine and saliva of smokers and non-smokers Feyerabend, C.;T. Higenbottam;M. A. H. Russell
  8. The New England J. of Med. v.310 Measuring the exposure of infants to tobacco smoke Greenberg, R. A.;N. J. Haley;R. A. Etzel;F. A. Loda
  9. The chemistry of environmental tobacco smoke: composition and measurement Guerin, M. R.;R. A. Jenkins;B. A. Tomkins
  10. Am. Rev. Respir. Dis. v.140 Home air nicotine levels and urinary cotinine excretion in preschool children Henderson, F. W.;H. F. Reid;R. Morris;O. L. Wang;S. K. Hammond
  11. J. of Epidemiology and Community Health v.38 Biochemical markers of smoke absorption and self reported exposure to passive smoking Jarvos, M. J.;H. Tunstall-Pedoe;C. Feyerabend;C. Vesey;Y. Salloojoo
  12. American J. of Public Health v.77 Comparison of tests used to distinguish smokers from nonsmokers Javis, M.;H. Tunstall-Pedoe;C. Feyerabend;C. Vesey;Y. Saloojee
  13. Mutation Research v.222 Application of biochemical intake markers to passive smoking measurement and risk estimation Jarvis, M. J.
  14. Envir. International v.20 Assessment of personal exposures to environmental tabacco smoke in british nonsmokers Phillips, K.;D. A. Howard;D. Browne;J. M. Lewsley
  15. J. Work Envir. Health v.22 Assessment of air quality in stockholm by personal monitoring of nonsmokers for respirable suspended particles and environmental tobacco smoke Phillip, K.;M. C. Bentley;D. A. Howard;G. Alvan
  16. Rev. Mal. Resp. v.8 An interpretation of urinary cotinine values in smokers and non-smokers Roussel, G.;L. E. Quang;M. L. Migueres;D. Roche;O. G. Ekindjian
  17. British J. of addiction v.81 Use of urinary nicotine concentrations to estimate exposure and mortality from passive smoking in non-smokers Russel, M. A. H.;M. J. Jarvis;R. J. West
  18. Molucular Biology Reports v.13 Simultaneous estimation of nicotine and cotinine levels in biological fluids using high-resolution capillary column gas chromatography combined with solid phase extraction work-up Teeuwen, H. W. A.;R. J. W. Aalders;J. M. Van Rossum
  19. American J. of Public Health v.78 Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers Wall, M. A.;J. Johnson;P. Jacob;N. L. Benowitz
  20. British Med. J. v.2 Verification of smoking history in patients after infarction using urinary nicotine and cotinine measurements Wilcox, R. G.;J. Hughes;J. Roland