Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Localization and Developmental Changes of Dopamine $D_1$ and $D_2$ Receptor mRNAs in the Rat Brain

  • Kim, Myeong-Ok (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) ;
  • Choi, Wan-Sung (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) ;
  • Lee, Bong-Hee (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) ;
  • Cho, Kyung-Jae (Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University) ;
  • Seo, Sook-Jae (Department of Biology, College of Natural Sciences, Gyeongsang National University) ;
  • Kang, Sung-Goo (Department of Biology, College of Natural Sciences, Inje University) ;
  • Kim, Kyung-Jin (Department of Molecular Biology and Research Center for Cell Differentiation, College of Natural Sciences, Seoul National University) ;
  • Baik, Sang-Ho (Department of Anatomy, College of Medicine, Seoul National University)
  • Published : 1997.09.01
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Abstract

Dopamine plays diverse roles in the fetal brain development and differentiation. However, the development of the dopaminergic neurons and its receptors has not been fully understood. In our studies, in situ hybridization and immunohistochemical methods were used to investigate the ontogeny of dopaminergic neurons and its receptor subtypes during the fetal development of the rat. In situ hybridization data showed that dopamine $D_1$ and $D_2$ receptor mRNAs were expressed in the ventricular and subventricular zones of ganglionic eminence, thalamus, hypothalamus, and cortical neuroepithelium on gestational day 13. Expression of dopamine $D_1$ and $D_2$ receptors during gestational days 17 and 19 reached the same or similar level of that in the adult brain. Expression of $D_1$ receptor mRNA preceded that of $D_2$ receptor mRNA in the early developmental stage, although this pattern was reversed with the sharp increase of $D_2$ receptor mRNA soon after. $D_2$ receptor mRNA was expressed in substantia nigra of mesencephalon of the fetal rat brain. However, $D_1$ receptor mRNA was not detected in substantia nigra. Our results indicate that dopamine might function in the fetal brain during the early gestational period.

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References

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