The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effect of Glycyrrhiza glabra Extracts on Immune Response

감초 추출물이 면역응답에 미치는 영향

  • Sim, Ho-Ki (Dept. of Faculty of Bioresources Science, Kyungsan University) ;
  • Park, Mu-Hee (Dept. of Food Science and Technology, Yeungnam University) ;
  • Choi, Chung (Dept. of Food Science and Technology, Yeungnam University) ;
  • Bae, Man-Jong (Dept. of Faculty of Bioresources Science, Kyungsan University)
  • 심호기 (경산대학교 생명자원과학부) ;
  • 박무희 (영남대학교 식품가공학과) ;
  • 최청 (영남대학교 식품가공학과) ;
  • 배만종 (경산대학교 생명자원과학부)
  • Published : 1997.12.01
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Abstract

This study was conduced to investigate on immune response of the hot water extract(PHE), 50% methanol extract(PME) and acetone extract(PAE) from Glycyrrhiza glabra. The experiment was carried out by phagocytosis, plaque forming cell(PFC), hemalysin titration(HY) and rosette forming cell(RFC) assay by using BALB/c mice. The results obtained from this study are as follow ; The effects of Glycyrrhiza glabra extracts on phagocytosis was tended to be slight increase in GME and GAE groups compared to the control group, but not significant. In the experiment of PFC and HY, the results of experiment groups which was given each samples were significantly higher than the control group. The result of rosette forming cell in GME and GAE groups were significantly higher than control group.

감초에서 분리한 각각의 추출물(GHE, GME, GAE)을 BALB/c mice에 투여하여 탐식작용, 용혈 반형성, 용혈소 역가 측정 및 rosette 형성 실험을 통해 감초가 면역응답에 미치는 영역을 조사하였다. 1. 탐식능 측정에서 복강침출세포(PEC)와 비자세포(spleen cells)는 CONrns에 비하여 각각의 약물 투여군이 Candida parapsilosis에 대한 효과가 다소 높은 경향을 나타내었지만, 유의성은 없었다. 2. 용혈반 형성 및 용혈소 역가측정에서는 CON군에 비하여 GHE, GME 투여군 및 GAE 투여군이 높게 나타났다. 3. Rosette 형성에 대한 측정에서는 CON군에 비하여 GME, GAE 투여군이 높은 유의성을 나타내었다.

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