한국발생생물학회지:발생과생식 (Development and Reproduction)
- 제1권2호
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- Pages.117-124
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- 1997
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- 2465-9525(pISSN)
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- 2465-9541(eISSN)
마우스 부정소에서 Guanidinoacetate Methyltransferase의 발현
Guanidinoacetate Methyltransferase Expression in Mouse Epididymis
- Lee, Hang (College of Veterinary Medicine, Seoul National University) ;
- Lee, Mun-Han (College of Veterinary Medicine, Seoul National University)
- 발행 : 1997.12.01
초록
Guanidinoacetate N-methyltransferase (GAMT) catalyzes the last step of creatine biosynthesis and the resultant creatine plays an important role in cellular energy metabolism. GAMT is mainly found in liver, kidney as well as testis and epididymis. We have localized the site of creatine biosynthesis in mouse epididymis by immunoperoxidase staining of GAMT using anti-GAMT antibody. Gamt is extensively expressed in the microvilli of epididymal epithelial cells and also expressed weakly in the cyto plasm of the cells. The staining of GAMT was most prominent in the microvilli of proximal caput epididymis and the intensity was progressively diminished as the epididymal tubule proceeds toward caudal part. The result suggests that GAMT or Cr might be involved in sperm function and/or maturation process in epididymis.
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