Toxicological Research

  • 제13권4호
  • /
  • Pages.353-357
  • /
  • 1997
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  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Experimental Allergic Encephalomyelitis Study of Combined Vaccine (KGCC-95VI) Against Japanese Encephalitis and Hantaan Virus Infection

  • An, Chang-Nam (General Research Institute. Korea Green Cross Corp.,) ;
  • Shin, Kwang-Soon (Veterinary Research Institute, College of Veterinary Medicine Chungnam National University) ;
  • Yun, Hyo-In (Veterinary Research Institute, College of Veterinary Medicine Chungnam National University) ;
  • Park, Jong-Il (Toxicology Research Center, KRICT) ;
  • Cha, Shin-Woo (Toxicology Research Center, KRICT) ;
  • Shin, Hyeong-Soon (Department of Biotechnology, Inha University) ;
  • Kim, Chul-Joong (Veterinary Research Institute, College of Veterinary Medicine Chungnam National University)
  • 발행 : 1997.12.01
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초록

The possibility of the allergic encephalomyelitis caused by the combined vaccine (KGCC95VI) for the prophylaxis against Japanese encephalitis and Hantaan virus infection, recently developed by Korea Green Cross Corporation, was investigated in the Hartley guinea pigs. The KGCC-95VI was administered to the guinea pigs subcutaneously to sensitize the animals three times at one month intervals. There were no clinical signs or gross pathological findings. There were no abnormal histopathological findings at cerebrums, cerebellums, brain stems and the spinal cords. The concentration of myelin basic protein was 1.10 ng/dose quantified by ELISA, which met the guide4ine of below 2 ng/ml/dose recommended by American Society of Health -System Pharmacists(AHPS) Drug Information. Accordingly, the KGCC-95VI is considered not to induce any allergic immune responses which may lead to the experimental allergic encephalomyelitis.

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참고문헌

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