Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Experimental Allergic Encephalomyelitis Study of Combined Vaccine (KGCC-95VI) Against Japanese Encephalitis and Hantaan Virus Infection

  • An, Chang-Nam (General Research Institute. Korea Green Cross Corp.,) ;
  • Shin, Kwang-Soon (Veterinary Research Institute, College of Veterinary Medicine Chungnam National University) ;
  • Yun, Hyo-In (Veterinary Research Institute, College of Veterinary Medicine Chungnam National University) ;
  • Park, Jong-Il (Toxicology Research Center, KRICT) ;
  • Cha, Shin-Woo (Toxicology Research Center, KRICT) ;
  • Shin, Hyeong-Soon (Department of Biotechnology, Inha University) ;
  • Kim, Chul-Joong (Veterinary Research Institute, College of Veterinary Medicine Chungnam National University)
  • Published : 1997.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The possibility of the allergic encephalomyelitis caused by the combined vaccine (KGCC95VI) for the prophylaxis against Japanese encephalitis and Hantaan virus infection, recently developed by Korea Green Cross Corporation, was investigated in the Hartley guinea pigs. The KGCC-95VI was administered to the guinea pigs subcutaneously to sensitize the animals three times at one month intervals. There were no clinical signs or gross pathological findings. There were no abnormal histopathological findings at cerebrums, cerebellums, brain stems and the spinal cords. The concentration of myelin basic protein was 1.10 ng/dose quantified by ELISA, which met the guide4ine of below 2 ng/ml/dose recommended by American Society of Health -System Pharmacists(AHPS) Drug Information. Accordingly, the KGCC-95VI is considered not to induce any allergic immune responses which may lead to the experimental allergic encephalomyelitis.

Keywords

References

  1. AHPS Drug Information v.2 Japanese encephalitis virus vaccine American Society of Health-System Pharmacists (AHPS)
  2. Am. J. Trop. Med. Hyg. v.8 Ecological studies of Japanese encephalitis in Japan Buescher, E. L.;Scherer, W. F.
  3. Report of NIH. Kor. v.31 Antigenic analysis of JE virus isolated from mosquitoes (C. t) in Korea and the development of a rapid diagnosis for JE by using monoclonal antibody Cho, H.W.;Kim, C.L.;Ban, Nam, J.H. (et al.)
  4. J. Inf. Dis. v.168 The children's vaccine intiative will it work? Douglas, R.G.
  5. Provision #1996-8 Food and Drug Administration, Korea Guidelines for Safety Tests of Drugs
  6. N. Engl. J. Med. v.319 Protection against Japanese encephalitis by inactivated vaccine Hoke, C.H.;Nisalak, A.;Sagawhipa, N.(et al.)
  7. To assess the potential of a test compound to induce allergic encephalomyelitis in the guinea pig, personal communication Huntingdon Research Centre
  8. J. Korean. Soc. Microbiol. v.30 no.5 The quantitation of myelin basic protein using ELISA in the mouse brain-derived Vaccine: Hantavax and Japanese encephalitis Vaccine : Hantavax and Japanese encephalitis vaccine Kim, H.;Jang, Y.S.;An, C.N.;Kim, H.C.;Lee, H.W.
  9. Immunization for Japanese encephalitis Follow-up on the use of vaccine in children in Japan Kitaka M.
  10. J. Viol. Meth. v.38 Detection of african horse-sickness virus in infected spleens by a sandwich ELISA using two monoclonal antibodies specific for VP 7 Laviada, M.D.;Dominguez, M.B.;Sanchez-Vizcaino, J.M.
  11. J. Korean. Soc. Virol. v.18 Development of Vaccine against Hemorrhagic Fever with Renal Syndrome Lee, H.W.;An, C.N.
  12. WHO report Guidelines for mass immunization using Japanese encephalitis vaccines Oya, A.
  13. Mol. Brain Res. v.3 Expression of only one myelin basic protein allele in mouse is compatible with normal myelination Roch J.M.;Cooper, B.J.;Ramirez, M.;Matthieu, J.M.
  14. J. Korean Soc. Microbiol. v.27 Study on the ELISA method using monoclonal antibody for the detection of Hantaan virus Shin, K.S.
  15. Bull WHO v.63 Japanese encephalitis: current world-wide status Umenai, T.;Krzyko, R.;Bektimirov, T.A.(et al.)
  16. Vaccine v.6 Development of inactivated vaccine against virus causing hemorrhagic fever with renal syndrome Yamanishi, K.;Tomishita, O.;Tamura, M.