Residue of Clindamycin in the Muscles of Eel and Flounder Infected by Streptococcus sp. by HPLC

  • Jang, Won-Cheoul (Department of Chemistry, College of Natural Science, Dankook University, Anseodong, 330-714, Cheonan) ;
  • Shim, Sang-Kyun (Department of Chemistry, College of Natural Science, Dankook University, Anseodong, 330-714, Cheonan) ;
  • Heo, Gang-Joon (Laboratory of Aquatic Animal Diseases, College of Veterinary Medicine, Chungbuk National University, Cheongju 360-763)
  • Published : 1997.09.01

Abstract

Residue and recoveries of clindamycin were investigated by reversed-phase high performance liquid chromatography (RP-HPLC) which was infected for the control of streptcoccal infection in Anguilla japonica and Paralichthys olivaceusis. Detection limit was 0.1 ppm. Recoveries of clindamycin in muscles of flounder and eel were 80.4 and 78.8%, respectively. The clindamycin in eel and flounder was detected up to 13 and 15 days after dosing, respectively.

Keywords

References

  1. J. Fish Dis. v.8 Evaluation of antimicrobial compounds for the control of bacterial kidney disease in rainbow trout, Salmo gairdneri Austin, B.
  2. Bacterial Fish Pathogens Control of bacterial fish disease Austin, B.;D. A. Austin
  3. Eur. J. Drug Metab. Pharmacok v.3 no.1 Distribution an metabolism of antibiotics in the whole animal. clindamycin in the rat Brodasky, T. F.;C. Lewis;T. E. Eble
  4. J. Vet. Pharmacol. Ther. v.13 Tissue concentrations of clindamycin after multiple oral doses in normal cats Brown, S. A.(et al.)
  5. International J. of Dermatology v.22 no.5 Percutaneous absorption of clindamycin in the pig and the rat. Gray, J. E.
  6. Kor. J. Food Hyg. v.7 no.2;3 Diseasea of aquaculture animals and prevenion of drug residues Heo, G. J.;Shin, K. S.;Lee, M. H.
  7. Bull. Japan. Soc. Sci. Fish. v.44 A comparative study of fish pathogenic streptococcus sp. isolated from saltwater and freshwater and fishes Kusuda, R.;I. Komasu
  8. Seriolar quinqueradiata. Fish Pathol. v.20 The in vitro effect of macrolide antibiotics and lincomycin on Streptococcus sp., the etiological agent of streptococcal infection in yellowtall, Kusuda, R.;S. Onizaki
  9. J. Applied Bacteriol v.40 An investigation of antibiotic and drug residues in fish McCracken, A.;S. Fidgeon;J. J. O'Brien;D. Anderson
  10. J. Chromatogr. v.309 no.1 High-performance liquid chromatographic assay of pirlimycin in human serum and urine using 9-fluorenylmethyl-chloroformate Shah, J. A.;D. J. Weber
  11. Nippon Suisian gakkaish v.54 In vitro antibacterial activity of josamycin against Streptococcus sp. and various fish pathogenic bacteria Takemaru, I.;R. Kusuda
  12. Nippon Suisian gakkaish v.54 Chemotherapeutic effect of josamycin against natural streptococcal infection in cultured yellowtail Takemaru, I.;R. Kusuda
  13. Transactions of the American Fisheries Society v.83 Development of diseases resistant strains of fish Wolf, L E