Toxicological Research

한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

토끼에서 EPO(Erythropoietin)의 안점막자극성 및 피부자극성시험

A Study on Ocular and Skin Irritation Test of EPO(Erythropoietin)

  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 남정석 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 이석만 (서울대학교 수의과대학 공중보건학교실) ;
  • 양재만 (서울대학교 수의과대학 공중보건학교실) ;
  • 이학모 (서울대학교 수의과대학 공중보건학교실) ;
  • 박재학 (서울대학교 수의과대학 실험동물의학교실) ;
  • 송동호 ((주)녹십자) ;
  • 유선희 ((주)녹십자)
  • 발행 : 1997.06.01
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초록

This test was performed to evaluate the ocular and skin irritation of EPO (Erythropoietin). The results as follows: 1. Ocular irritation test There were no observed clinical signs, body weght changes by EPO during experimental period. The acute ocular irritation index(A.O.I.), mean ocular irritation index(M.O.I.) and Day-7 individual ocular irritation index(I.O.I.) of EPO at dose of 1000U and 10, 000U were 0, respectively. Therefore we evaluated that EPO was non-toxic to eyes. 2. Skin irritation test There were no observed clinical signs, body weght changes and gross pathologic findings by EPO during experimental period. There were no observed erythema, eschar formation and edema formation on intact and abraded skin treated by EPO. The primary irritation index(P.I.I.) of EPO at dose of 1000U and 10, 000U were 0, respectively and were evaluated none irritating product about skin irritation.

키워드

참고문헌

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