Journal of Chest Surgery

  • 제30권1호
  • /
  • Pages.11-16
  • /
  • 1997
  • /
  • 2765-1606(pISSN)
  • /
  • 2765-1614(eISSN)
대한심장혈관흉부외과학회 (The Korean Society for Thoracic and Cardiovascular Surgery)
권호 표지

마그네슘 농도변화에 따른 흰쥐의 심근 보호효과

Protective Effect on the Rat's Myocardium with Changes in Magnesium Concentrations

  • 홍치욱 (경희대학교 의과대학 흉부외과학 교실) ;
  • 조규석 (경희대학교 의과대학 흉부외과학 교실) ;
  • 유세영
  • Hong, Chi-Uk (Dept. of Thoracic and Cardiovascular Surgery, Kyung Hee University) ;
  • Jo, Gyu-Seok (Dept. of Thoracic and Cardiovascular Surgery, Kyung Hee University) ;
  • Yu, Se-Yeong
  • 발행 : 1997.01.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The Increasing use of coronary perfusates for the protection of the human heart during ischemic cardiac arrest has placed great emphasis on the need for a rational and safe formulation. For the purpose of this study isolated rat hearts were connected to retrograde nonworking perfusion system proposed by Langendorff, and then perfused for 20 minutes by coronary infusates of magnesium concentration of 1.66 m Mol per liter(group A, n: 10) or 15mMo1 per liter(group B, n: 10). After 20 minutes perfusion, cold cardioplegic solution (modified St. Thomas'Hospital solution) was infused for 2 minutes, and prepared within 4$^{\circ}C$ Krebs-Henseleit solution. Finally, 20 minutes of cononay reprsfuslon was reestablished after I hour of cold ischemic cardiac arrest. Hemodynamic parameters (heart rate, left ventricular pressure, $\pm$ dp/dt max. and coronany flow) and enzymes assay (creatine phosphokinase, lactic dehydrogenase and flutamic oxaloacetic transaminase) were performed each other at whic rat heart was perfused for 20 minutes and reperfused for 20 minutes thereafter. There were significant differences in the recovery rate of heart rate, systolic left ventricular pressure, + dp/dt max, and coronary flow and reperfusion-perfusion ratio of creatine phosphokinase(P < 0.05). But, there were no signicant differences in the recovery rate of dp/dt max, and reperfunion-perfusion ratio of lactic dehydrogenase and glutamic oxaloacetic acid (P > 0.05).

키워드

참고문헌

  1. Circulation v.54 Cellular protection during myocardial ischemia. The development and characterization of a procedure for the induction of reversible ischemic arrest Hearse DJ;Stewart DA;Braimbridge MV
  2. J Thorac Cardiovasc Surg v.74 Cold cardioplegia jor continuous coronary perfusion? Report on preliminary clinical experience as assessed cytochemically Braimbridge MV;Chayen J;Bitensky L;Hearse DJ;Jynge P;Cankovic-Darracott S
  3. J Thorac Cardiovasc Surg v.73 Myocardial protection during ischemic cardiac arrest. A possible hazard with calcium free cardioplegic infusates Jynge P;Hearse DJ;Braimbridge MV
  4. J Cardiovasc Surg v.16 Myocardial resistance and tolerance to ischemia. Physiological and biochemical basis Bretschneider HJ;Hubner G;Knoll D;Lohr B;Nordbeck H;Spieckermann PG
  5. J Thorac Cardiovasc Surg v.63 Induced ischemic arrest. Clinical experience with cardioplegia in open-heart surgery Kirsch U;Rodewald G;Kalmar P
  6. Surgery v.74 Functional metabolic and morphologic effects of potassium-induced cardioplegia Gay WA;Ebert PA
  7. Cirulation v.54 no.SUP. 3 Improved mycardial performance after aortic cross clamping by combining pharmacologic arrest with topical hypothermia Nelson RL;Goldstein SM;McConnell DH;Maloney JV;Buckberg GD
  8. Arch Surg v.110 Experimental evaluation of coronary infusates in dogs Raju S;Gibson WJ;Heath B;Lockhart V;Conn H
  9. J Thorac Cardiovasc Surg v.67 Retroperfusion of the heart with a solution of glucose, insulin, and potassium during anoxic arrest Lolley DM;Hewitt RL;Drapanas T
  10. Ann Thorac Surg v.23 Hypothermic coronary perfusion for intraoperative cardioplegia Fisk RL;Gelfand ET;Callaghan JC
  11. J Thorac Cardiovasc Surg v.72 Myocardial protection during bypass and arrest. A possible hazard with lactate-containing infusates Hearse DJ;Stewart DA;Braimbridge MV
  12. J Thorac Cardiovasc Surg v.75 Myocardial protection during ischemic cardiac arrest. The importance of magnesium in cardioplegic infusates Hearse DJ;Stewart DA;Braimbridge MV
  13. Circ Res v.36 Hypothermic arrest and potassium arrest. Metabolic and myocardial protection during elective cardiac arrest Hearse DJ;Stewart DA;Braimbridge MV
  14. Pflugers Arch v.61 Untersuchungen am iiberlebenden Saugetierherzen Langendorff O
  15. Hoppe Seylers Z Physiol Chem v.210 Untersuchungen uber die Harnstoffbild ng im Tierkorper Krebs HA;Henseleit K
  16. Preparation of Krebs-Ringer phosphate and bicarbonate solution, Manometric Techniques, Minneapolis Umbreit WW;Burris RH;Stauffer JF
  17. Circ Res v.33 Magnesium in heart muscle Polimeni PI;Page E
  18. J Physiol v.204 Magnesium exchange in rat ventricle Page E;Polimeni PI
  19. Pharmacol Rev v.13 Concept of carrier transport and its corollaries in pharmacology Wilbrant W.;Rosenberg T.
  20. Can Med Assoc J v.9 Ischemic heart disease, water hardness and myocardial magnesium Anderson TW;Neri LC;Schreiber GB;Talbot FDF;Zalrojewski A
  21. Am Heart J v.43 Water and electrolyte content of cardiac and skeletal muscle in heart failure and myocardial infarction Iseri LT;Alexander LC;McCaughey RS;Boyle AM;Myers GB
  22. Lancet v.2 Heart Muscle magnesium, potassium and zinc cocentrations after sudden death from heart disease Chipperfield B.;Chipperfield JR
  23. Am J Pathol v.67 Myocardial calcium and magnesium in acute ischemic injury Shen AC;Jennings RB
  24. Am Heart J v.82 The role of magnesium in digitalis toxictiy Seller RH
  25. Circulation v.52 Studies on magnesium's mechanism of action in digitalis-induced arrhythmias Specter MJ;Schweizer E;Goldman RH