대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)
- 제23권3호
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- Pages.86-91
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- 1997
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- 1226-2587(pISSN)
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- 2288-9507(eISSN)
Development of Whitenin Agents by Synthesis of Polyhydroxy Aromatic Compounds
- Hyun-Ho Lee (SpecialtyChemical Researchlnstitute, LGChemical Ltd.) ;
- You (Cosmetic Research Insti lute, LG Chemical Ltd.)
- 발행 : 1997.09.01
초록
Some natural polyhydroxy aromatic compounds have inhibitory activity against tyrosinase, key enzyme for formation of melanin pigment. We examined the structure-activity relationship of the natural polyhydrowy aromatic compounds and synthesized a number of new derivetives through various methods. Skin lightening effects of these compounds were examined through inhibition of mushroom tyrosinase and inhibitory of melanogenesis on B-16 melanoma cells. These new compounds showed strong inhibitory activity against tyrosinase. Good lightening effects sue to inhibition of melanogenesis were observed from several resorcinol and pyrogallol derivatives. In toxicological tests such as skin primary irritation and sensitization, the above compounds were sufficiently safe for cosmetic use.
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