Archives of Pharmacal Research

  • 제20권6호
  • /
  • Pages.633-636
  • /
  • 1997
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  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Platelet-Activating Factor Antagonistic Activity and ^13C NMR Assignment of Pregomisin and Chamigrenal from Schisandra chinensis

  • Lee, Im-Seon (Natural Products Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Jung, Keun-Young (Natural Products Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Oh, Sei-Ryang (Natural Products Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Dong-Seon (Natural Products Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Jung-Hee (Natural Products Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Jung-Joon (Natural Products Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyeong-Kyu (Natural Products Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam University) ;
  • Kim, Eun-Hee (Magnetic Resonance Group, Korea Basic Science Institute) ;
  • Cheong, Chae-Joon (Magnetic Resonance Group, Korea Basic Science Institute)
  • 발행 : 1997.12.01
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초록

In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits of Schizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the $IC_{50}$ values were $4.8{\times}10^{-5} M and 1.2{\times}10^{-4}M,$ respectively. In addition, the $^{13}C$ NMR assignments of 1 and 2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.

키워드

참고문헌

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